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Polymorphisms in ER...
Polymorphisms in ERBB4 and TACR1 associated with dry mouth in clozapine-treated patients
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- Puolakka, Hanna (författare)
- Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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- Solismaa, Anssi (författare)
- Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, The Pirkanmaa Wellbeing Services County, Tampere, Finland
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- Lyytikäinen, Leo-Pekka (författare)
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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- Viikki, Merja (författare)
- Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, The Wellbeing Services County of Ostrobothnia, Seinäjoki, Finland
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- Seppälä, Niko (författare)
- Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, Satasairaala Hospital, The Satakunta Wellbeing Services County, Pori, Finland
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- Mononen, Nina (författare)
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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- Lehtimäki, Terho (författare)
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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- Kampman, Olli (författare)
- Umeå universitet,Psykiatri,Department of Psychiatry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, The Pirkanmaa Wellbeing Services County, Tampere, Finland; Department of Clinical Medicine (Psychiatry), Faculty of Medicine, University of Turku, Turku, Finland; Department of Psychiatry, The Wellbeing Services County of Ostrobothnia, Vaasa, Finland
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(creator_code:org_t)
- Cambridge University Press, 2024
- 2024
- Engelska.
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Ingår i: Acta Neuropsychiatrica. - : Cambridge University Press. - 0924-2708 .- 1601-5215.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Sialorrhea is a common and uncomfortable adverse effect of clozapine, and its severity varies between patients. The aim of the study was to select broadly genes related to the regulation of salivation and study associations between sialorrhea and dry mouth and polymorphisms in the selected genes.Methods: The study population consists of 237 clozapine-treated patients, of which 172 were genotyped. Associations between sialorrhea and dry mouth with age, sex, BMI, smoking, clozapine dose, clozapine and norclozapine serum levels, and other comedication were studied. Genetic associations were analyzed with linear and logistic regression models explaining sialorrhea and dry mouth with each SNP added separately to the model as coefficients.Results: Clozapine dose, clozapine or norclozapine concentration and their ratio were not associated with sialorrhea or dryness of mouth. Valproate use (p=0.013) and use of other antipsychotics (p=0.015) combined with clozapine were associated with excessive salivation. No associations were found between studied polymorphisms and sialorrhea. In analyses explaining dry mouth with logistic regression with age and sex as coefficients, two proxy-SNPs were associated with dry mouth: epidermal growth factor receptor 4 (ERBB4) rs3942465 (adjusted p=0.025) and tachykinin receptor 1 (TACR1) rs58933792 (adjusted p=0.029).Conclusion: Use of valproate or antipsychotic polypharmacy may increase the risk of sialorrhea. Genetic variations in ERBB4 and TACR1 might contribute to experienced dryness of mouth among patients treated with clozapine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- adverse effects
- clozapine
- pharmacogenetics
- sialorrhea
- xerostomia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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