Sökning: id:"swepub:oai:DiVA.org:umu-29882" >
Detection of polyun...
Detection of polyunsaturated omega-6 fatty acid in human malignant prostate tissue by 1D and 2D high-resolution magic angle spinning NMR spectroscopy
-
- Stenman, Katarina (författare)
- Umeå universitet,Diagnostisk radiologi
-
- Hauksson, Jón (författare)
- Umeå universitet,Radiofysik
-
- Gröbner, Gerhard (författare)
- Umeå universitet,Kemiska institutionen
-
visa fler...
-
- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
-
- Bergh, Anders (författare)
- Umeå universitet,Patologi
-
- Riklund, Katrine (författare)
- Umeå universitet,Diagnostisk radiologi
-
visa färre...
-
(creator_code:org_t)
- 2009-11-17
- 2009
- Engelska.
-
Ingår i: Magnetic Resonance Materials in Physics, Biology and Medicine. - Berlin : Springer. - 0968-5243 .- 1352-8661. ; 22:6, s. 327-331
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECT: Polyunsaturated omega-6 fatty acids (PUFAs) have been shown to promote prostate cancer. Here, we describe the use of HRMAS NMR spectroscopy to detect omega-6 PUFA species in prostate tissues. MATERIALS AND METHODS: Samples originating from non-malignant (n = 54) and malignant (n = 27) prostate tissues (from 27 prostatectomized men) were studied by 1D (1)H, 2D (1)H-(1)H and (1)H-(13)C HRMAS NMR spectroscopy followed by histopathological characterization. RESULTS: HRMAS NMR proved to be a powerful, non-destructive method to identify and characterize PUFAs. The omega-6 PUFA was found in 15% of examined human prostate tumors. CONCLUSION: It is possible to detect PUFAs in prostate tissues using our NMR-based spectroscopic approach.
Nyckelord
- HRMAS NMR
- Omega-6 & omega-3 fatty acids
- PUFA
- Prostate cancer
- PCa
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas