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Liver transplantati...
Liver transplantation for familial amyloidotic polyneuropathy : impact on Swedish patients' survival
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- Okamoto, Sadahisa (författare)
- Umeå universitet,Medicin,Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
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- Wixner, Jonas (författare)
- Umeå universitet,Medicin
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Obayashi, Konen (författare)
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Ando, Yukio (författare)
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- Ericzon, Bo-Göran (författare)
- Karolinska Institutet
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- Friman, Styrbjörn, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Uchino, Makoto (författare)
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- Suhr, Ole B (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2009-09-29
- 2009
- Engelska.
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Ingår i: Liver transplantation. - : John Wiley & Sons. - 1527-6465 .- 1527-6473. ; 15:10, s. 1229-1235
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Liver transplantation (LTx) for familial amyloidotic polyneuropathy (FAP) is an accepted treatment for this fatal disease. However, the long-term outcome with respect to that of nontransplanted patients has not been fully elucidated. The aim of this study was to compare the long-term survival of Swedish LTx FAP patients with that of historical controls, especially with respect to the age at onset of the disease and gender. In order to evaluate the outcome of LTx as a treatment for FAP, survival was calculated from the onset of disease. One hundred forty-one FAP patients, 108 transplanted and 33 not transplanted, were included in the study. Significantly increased survival was noted for LTx patients in comparison with controls. The outcome was especially favorable for those with an early onset of the disease (age at onset < 50 years) in comparison with early-onset controls (P < 0.001). In contrast, no significant difference for late-onset cases (> or = 50 years) was found. Transplanted late-onset females had significantly improved survival in comparison with transplanted late-onset males (P = 0.02). We were unable to find significant differences in survival between patients with long (> or = 7 years) or short (<7 years) disease duration at transplantation. The survival of male patients with late-onset disease appeared not to improve with LTx. LTx is an efficacious treatment for improving the survival of early-onset FAP patients. Further studies are needed to analyze the cause of the poorer outcome for late-onset male patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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