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Macrophage inhibito...
Macrophage inhibitory cytokine 1 : a new prognostic marker in prostate cancer.
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- Brown, David A (författare)
- St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia.;Univ New S Wales, Sydney, NSW, Australia.
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- Lindmark, Fredrik (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden.
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- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Preoperat Sci, Umea, Sweden.
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- Bälter, Katarina (författare)
- Karolinska Institutet
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- Adami, Hans-Olov (författare)
- Karolinska Institutet
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- Zheng, Sigun L (författare)
- Wake Forest Univ, Ctr Human Genom, Winston Salem, NC 27109 USA.
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- Xu, Jianfeng (författare)
- Wake Forest Univ, Ctr Human Genom, Winston Salem, NC 27109 USA.
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- Isaacs, William B (författare)
- Johns Hopkins Univ, Dept Urol, Baltimore, MD USA.
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- Grönberg, Henrik (författare)
- Karolinska Institutet
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- Breit, Samuel N (författare)
- St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia.;Univ New S Wales, Sydney, NSW, Australia.
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- Wiklund, Fredrik E (författare)
- Karolinska Institutet
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St Vincents Hosp, Ctr Appl Med Res, Sydney, NSW 2010, Australia;Univ New S Wales, Sydney, NSW, Australia. Institutionen för strålningsvetenskaper (creator_code:org_t)
- AMER ASSOC CANCER RESEARCH, 2009
- 2009
- Engelska.
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Ingår i: Clinical Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 1078-0432 .- 1557-3265. ; 15:21, s. 6658-6664
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- PURPOSE: High serum levels of macrophage inhibitory cytokine 1 (MIC-1) are strongly associated with metastatic prostate cancer, suggesting MIC-1 is a biomarker for prostate cancer prognosis. EXPERIMENTAL DESIGN: We conducted a prospective cohort study of 1,442 Swedish men with a pathologically verified diagnosis of prostate cancer between 2001 and 2003. Blood was drawn either pretreatment (n = 431) or posttreatment (n = 1,011) and cases were followed for a mean time of 4.9 years (range, 0.1-6.8 years). RESULTS: MIC-1 serum levels independently predicted poor cancer-specific survival with an almost 3-fold higher cancer death rate in patients with serum levels in the highest quartile compared with men with serum levels in the lowest quartile (adjusted hazard ratio, 2.98; 95% confidence interval, 1.82-4.68). Pretreatment MIC-1 levels revealed an even stronger association with disease outcome with an 8-fold higher death rate in the highest compared with the lowest category (adjusted hazard ratio, 7.98; 95% confidence interval, 1.73-36.86). Among patients considered to have localized disease, MIC-1 significantly increased the discriminative capacity between indolent and lethal prostate cancer compared with the established prognostic markers clinical stage, pathologic grade, and prostate-specific antigen level (P = 0.016). A sequence variant in the MIC-1 gene was associated with decreased MIC-1 serum levels (P = 0.002) and decreased prostate cancer mortality (P = 0.003), suggesting a causative role of MIC-1 in prostate cancer prognosis. CONCLUSIONS: Serum MIC-1 concentration is a novel biomarker capable of predicting prostate cancer prognosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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Brown, David A
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Lindmark, Fredri ...
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Stattin, Pär
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Bälter, Katarina
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Adami, Hans-Olov
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Zheng, Sigun L
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visa fler...
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Xu, Jianfeng
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Isaacs, William ...
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Grönberg, Henrik
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Breit, Samuel N
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Wiklund, Fredrik ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Hälsovetenskap
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Clinical Cancer ...
- Av lärosätet
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Umeå universitet
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Mälardalens universitet
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Karolinska Institutet