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Ozone exposure enha...
Ozone exposure enhances mast-cell inflammation in asthmatic airways despite inhaled corticosteroid therapy.
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- Stenfors, Nikolai (författare)
- Umeå universitet,Lungmedicin
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- Bosson, Jenny (författare)
- Umeå universitet,Lungmedicin
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- Helleday, Ragnberth (författare)
- Umeå universitet,Lungmedicin
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- Behndig, Annelie F (författare)
- Umeå universitet,Lungmedicin
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- Pourazar, Jamshid (författare)
- Umeå universitet,Lungmedicin
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- Törnqvist, Håkan (författare)
- Umeå universitet,Lungmedicin
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Kelly, F J (författare)
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Frew, A J (författare)
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- Sandström, Thomas (författare)
- Umeå universitet,Lungmedicin
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Mudway, I S (författare)
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- Blomberg, Anders (författare)
- Umeå universitet,Lungmedicin
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(creator_code:org_t)
- 2010-01-04
- 2010
- Engelska.
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Ingår i: Inhalation Toxicology. - : Informa Healthcare. - 0895-8378 .- 1091-7691. ; 22:2, s. 133-139
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Asthmatics are recognised to be more susceptible than healthy individuals to adverse health effects caused by exposure to the common air pollutant ozone. Ozone has been reported to induce airway neutrophilia in mild asthmatics, but little is known about how it affects the airways of asthmatic subjects on inhaled corticosteroids. We hypothesised that ozone exposure would exacerbate the pre-existent asthmatic airway inflammation despite regular inhaled corticosteroid treatment. Therefore, we exposed subjects with persistent asthma on inhaled corticosteroid therapy to 0.2 ppm ozone or filtered air for 2 h, on 2 separate occasions. Lung function was evaluated before and immediately after exposure, while bronchoscopy was performed 18 h post exposure. Compared to filtered air, ozone exposure increased airway resistance. Ozone significantly enhanced neutrophil numbers and myeloperoxidase levels in airway lavages, and induced a fourfold increase in bronchial mucosal mast cell numbers. The present findings indicate that ozone worsened asthmatic airway inflammation and offer a possible biological explanation for the epidemiological findings of increased need for rescue medication and hospitalisation in asthmatic people following exposure to ambient ozone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Airway inflammation
- air pollution
- BAL
- bronchial mucosa
- myeloperoxidase
- neutrophil
- Lung diseases
- Lungsjukdomar
- lungmedicin
- Lung Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Stenfors, Nikola ...
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Bosson, Jenny
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Helleday, Ragnbe ...
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Behndig, Annelie ...
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Pourazar, Jamshi ...
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Törnqvist, Håkan
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visa fler...
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Kelly, F J
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Frew, A J
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Sandström, Thoma ...
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Mudway, I S
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Blomberg, Anders
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Inhalation Toxic ...
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Umeå universitet