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Does the autonomic ...
Does the autonomic nervous system play a role in the development of insulin resistance? : a study on heart rate variability in first-degree relatives of type 2 diabetes patients and control subjects
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- Lindmark, Stina (författare)
- Umeå universitet,Medicin
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- Wiklund, Urban (författare)
- Umeå universitet,Klinisk fysiologi,Centrum för medicinsk teknik och fysik (CMTF)
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- Bjerle, P (författare)
- Umeå universitet,Klinisk fysiologi
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- Eriksson, JW (författare)
- Uppsala universitet,Umeå universitet,Medicin,Endokrin diabetes och metabolism
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(creator_code:org_t)
- 2003-04-29
- 2003
- Engelska.
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Ingår i: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 20:5, s. 399-405
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aims To investigate dysregulation of the autonomic nervous system as a potential mechanism for early insulin resistance in the development of Type 2 diabetes. Methods Thirteen healthy individuals with first-degree relatives with Type 2 diabetes (R) were compared with 14 control subjects without family history of diabetes (C), matched for age, body mass index and sex. An oral glucose tolerance test and a hyperinsulinaemic euglycaemic clamp were performed. Analysis of heart rate variability during rest, controlled breathing, an orthostatic manoeuvre and a standardized physical stress (cold pressor test (CPT)), were used to evaluate the activity of the autonomic nervous system. Results Fasting blood glucose, HbA1c and serum insulin were similar in the R and C groups. The M-value, reflecting insulin sensitivity, did not differ significantly between the groups. Total spectral power and high-frequency power were lower in R during controlled breathing (P = 0.05 and P = 0.07, respectively), otherwise there were no significant differences between R and C in heart rate variability. However, low-frequency (LF)/high-frequency (HF) spectral power ratio during CPT, reflecting sympathetic/parasympathetic balance, was negatively associated with insulin sensitivity (r = −0.53, P = 0.006). When all subjects were divided into two groups by the mean M-value, the low M-value group displayed an overall higher LF/HF ratio (P = 0.04). HF power was lower in the low M-value group during controlled breathing and CPT (P = 0.01 and P = 0.03, respectively). Conclusion An altered balance of the parasympathetic and sympathetic nervous activity, mainly explained by an attenuated parasympathetic activity, might contribute to the development of insulin resistance and Type 2 diabetes.
Nyckelord
- insulin sensitivity
- Type 2 diabetes
- autonomic nervous system
- heart rate variability
- spectral analysis
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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