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Fatty acid amide hy...
Fatty acid amide hydrolase in prostate cancer : association with disease severity and outcome, CB1 receptor expression and regulation by IL-4
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- Thors, Lina (författare)
- Umeå universitet,Farmakologi
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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- Persson, Emma (författare)
- Umeå universitet,Onkologi
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- Hammarsten, Peter (författare)
- Umeå universitet,Patologi
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- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
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- Egevad, Lars (författare)
- Karolinska Institutet
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Granfors, Torvald (författare)
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- Fowler, Christopher J (författare)
- Umeå universitet,Farmakologi
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(creator_code:org_t)
- 2010-08-19
- 2010
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 5:8, s. e12275-
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Recent data have indicated that there may be a dysregulation of endocannabinoid metabolism in cancer. Here we have investigated the expression of the endocannabinoid metabolising enzyme fatty acid amide hydrolase (FAAH) in a well characterised tissue microarray from patients diagnosed with prostate cancer at transurethral resection for voiding problems. Methodology/Principal Findings FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer. CB1 receptor immunoreactivity (CB1IR) scores were available for this dataset. FAAH-IR was seen in epithelial cells and blood vessel walls but not in the stroma. Tumour epithelial FAAH-IR was positively correlated with the disease severity at diagnosis (Gleason score, tumour stage, % of the specimen that contained tumour) for cases with mid-range CB1IR scores, but not for those with high CB1IR scores. For the 281 cases who only received palliative therapy at the end stages of the disease, a high tumour epithelial FAAH-IR was associated with a poor disease-specific survival. Multivariate Cox proportional-hazards regression analyses indicated that FAAH-IR gave additional prognostic information to that provided by CB1IR when a midrange, but not a high CB1IR cutoff value was used. Interleukin-4 (IL-4) receptor IR was found on tumour epithelial cells and incubation of prostate cancer PC-3 and R3327 AT1 cells with IL-4 increased their FAAH activity. Conclusions/Significance Tumour epithelial FAAH-IR is associated with prostate cancer severity and outcome at mid-range, but not high, CB1IR scores. The correlation with CB1IR in the tumour tissue may be related to a common local dysregulation by a component of the tumour microenvironment.
Ämnesord
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Patobiologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Pathobiology (hsv//eng)
Nyckelord
- Pathology
- Patologi
- Pathology
- patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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