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Low sex steroid env...
Low sex steroid environment affects survival and steroid secretion of ovarian tumour cells in primary cultures
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- Taube, Magdalena (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Höckenström, T (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Isaksson, M (författare)
- Umeå universitet,Obstetrik och gynekologi
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visa fler...
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- Lindgren, Peter R (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Bäckström, Torbjörn (författare)
- Umeå universitet,Obstetrik och gynekologi
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: International Journal of Oncology. - 1019-6439 .- 1791-2423. ; 20:3, s. 589-594
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Ovarian epithelial tumours are considered to be endocrine related. The effects of an environment with low levels of the steroid hormones 17 beta-estradiol, testosterone or progesterone on cell survival and steroid secretion were studied in primary cell cultures derived from 25 patients suffering from epithelial ovarian tumours. Tumour cells cultured in 17 beta-estradiol and testosterone showed a reduced cell survival (-10.3 +/- 2.3% and -15.6 +/- 2.7% minimum survival respectively). This reduction was inversely proportional to hormone concentrations within the range studied. No similar effect was observed in the progesterone cultures. It was found that 17 beta-estradiol was secreted from the primary cell cultures and, interestingly, the amount of 17 beta-estradiol secreted increased with increasing levels of 17 beta-estradiol in the environment. Neither progesterone nor testosterone production was observed in any of the cultures studied. It is believed that 17 beta-estradiol has an antiapoptotic effect on ovarian surface epithelial (OSE) cells. Reduction of 17 beta-estradiol in the environment may inhibit this effect, resulting in reduced cell survival. The ability of ovarian epithelial tumour cells to secrete 17 beta-estradiol suggests that epithelial ovarian tumours play an active role in altering their own hormonal environment, promoting tumour progression.
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- art (ämneskategori)
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