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Dopamine D2 recepto...
Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: Association study and meta-analysis
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- Jönsson, E G (författare)
- Karolinska Institutet
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- Sillén, A (författare)
- Karolinska Institutet
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Vares, M (författare)
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- Ekholm, B (författare)
- Umeå universitet,Institutionen för klinisk vetenskap
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- Terenius, L (författare)
- Karolinska Institutet
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Sedvall, G C (författare)
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(creator_code:org_t)
- 2003-01-22
- 2003
- Engelska.
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Ingår i: American Journal of Medical Genetics. - : Wiley. - 0148-7299 .- 1096-8628. ; 119B:1, s. 28-34
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- An association has been reported between a dopamine D(2) receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, chi(2) = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61-15.12). The association was detected only in men. The results were supported by a meta-analysis of all published case-control studies comprising a total of 9,152 subjects (chi(2) = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16-1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia. Copyright 2003 Wiley-Liss, Inc.
Nyckelord
- genetics
- dopamine D2 receptor gene locus (DRD2)
- dopamine receptors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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