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Low endoglin vascul...
Low endoglin vascular density and Ki67 index in Gleason score 6 tumours may identify prostate cancer patients suitable for surveillance
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- Josefsson, Andreas, 1979- (författare)
- Umeå universitet,Patologi,Prostatacancer gruppen
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- Wikström, Pernilla (författare)
- Umeå universitet,Patologi
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- Egevad, Lars (författare)
- Karolinska Institutet
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- Granfors, Torvald (författare)
- Department of Urology, Central Hospital Västerås, Västerås, Sweden
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- Karlberg, Lars (författare)
- Department of Urology, Central Hospital Västerås, Västerås, Sweden
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- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2012-03-27
- 2012
- Engelska.
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa Healthcare. - 0036-5599 .- 1651-2065. ; 46:4, s. 247-257
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: The aim of this study was to explore whether vascular density and tumour cell proliferation are related to the risk of prostate cancer death in patients managed by watchful waiting. Material and methods. From a consecutive series of men diagnosed with prostate cancer at transurethral resection in 1975-1990, tissue microarrays (TMAs) were constructed. A majority of men had no metastases at diagnosis and were followed by watchful waiting (n = 295). The TMAs were stained for Ki67, endoglin and factor VIII-related antigen (vWf).Results: In univariate Cox analyses, increased Ki67 index, endoglin vascular density and vWf vascular density were associated with shorter cancer-specific survival. Ki67 index and endoglin vascular density added independent prognostic information to clinical stage, estimated tumour size and Gleason score (GS) in multivariate Cox analysis. In GS 6 tumours, high Ki67 index and high endoglin vascular density identified patients with poor outcome. After 15 years of follow-up not a single man out of 34 men with low staining for both markers (35% of all GS 6 tumours) had died of prostate cancer, in contrast to 15 prostate cancer deaths among the remaining 63 men with GS 6 tumours (65% cumulative risk of prostate cancer death). vWf vascular density in benign areas was a prognostic marker in GS 6 and 7 tumours.Conclusions: Men with GS 6 tumours with both low Ki67 index and endoglin vascular density staining scores have a low risk of progression. Additional studies are needed to test whether these two markers can be applied to core biopsies to select patients suitable for surveillance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- endoglin
- Ki67
- prostate cancer
- prognostic markers
- TINT
- vWf
- Immunohistokemi
- prognostiska markörer
- Pathology
- patologi
- Pathology
- patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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