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Brain activation pa...
Brain activation patterns in major depressive disorder and work stress-related long-term sick leave among swedish females
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- Sandström, Agneta (författare)
- Remonthagen Stroke och hjärnskadecenter, Östersund, Sweden
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- Säll, Roland (författare)
- Umeå universitet,Psykiatri
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- Peterson, Jonas (författare)
- Umeå universitet,Medicin,Institutionen för folkhälsa och klinisk medicin
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- Salami, Alireza (författare)
- Umeå universitet,Fysiologi,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper
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- Larsson, Anne (författare)
- Umeå universitet,Radiofysik,Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)
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- Olsson, Tommy (författare)
- Umeå universitet,Medicin
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- Nyberg, Lars (författare)
- Umeå universitet,Diagnostisk radiologi,Fysiologi,Institutionen för integrativ medicinsk biologi (IMB)
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(creator_code:org_t)
- 2012-01-10
- 2012
- Engelska.
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Ingår i: Stress. - London : Informa Healthcare. - 1025-3890 .- 1607-8888. ; 15:5, s. 503-513
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Deficits in executive and working-memory functioning associated with frontal lobe dysfunction are prominent in depression and work-related long-term sick leave (LTSL). This study used functional magnetic resonance imaging (fMRI) to investigate potential differences in brain activation patterns in these conditions. In addition, the function of the hypothalamic-pituitary-adrenal (HPA)-axis was examined and compared between groups. Since there is a clear overrepresentation of women in these diagnostic groups, and to ensure a more homogenous sample population, only women were included. To examine the neural correlates of relevant cognitive processes in patients on sick-leave > 90 days due to work-related LTSL, recently diagnosed patients with major depression (DSM-IV criteria, untreated), and healthy controls (n=10 each group), a 2-back working memory task and a visual long-term memory task were administered during fMRI scanning. HPA-axis functioning was investigated using a diurnal curve of saliva cortisol and a dexamethasone suppression test. Task performance was comparable among the three groups. Multivariate image analysis revealed that both memory tasks engaged a similar brain network in all three groups, including the prefrontal and parietal cortex. During the 2-back task, LTSL patients had significant frontal hypoactivation compared to controls and patients with depression. Saliva cortisol measurements showed a flattening of the diurnal rythmicity in LTSL patients compared to patients with depression and healthy contols. Taken together, these findings indicate that work stress-related LTSL and major depression are dissociable in terms of frontal activation and diurnal cortisol rhythmicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- blood pressure
- cohort study
- epidemiology
- high-grade glioma
- meningioma
- metabolic syndrome
- primary brain tumour
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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