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APOE influences on ...
APOE influences on neurosychological function after mild head injury : within-person comparisons
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- Sundström, Anna, 1969- (författare)
- Umeå universitet,Institutionen för psykologi
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- Marklund, Petter, 1968- (författare)
- Umeå universitet,Institutionen för psykologi
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- Nilsson, Lars-Göran, 1944- (författare)
- Department of Psychology, Stockholm University
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- Cruts, M. (författare)
- Depatrment of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Van Broeckhoven, C. (författare)
- Depatrment of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Institutionen för psykologi
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(creator_code:org_t)
- Minneapolis, Minn : Lancet Publications Inc. 2004
- 2004
- Engelska.
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Ingår i: Neurology. - Minneapolis, Minn : Lancet Publications Inc.. - 0028-3878 .- 1526-632X. ; 62:11, s. 1963-1966
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To examine the relationship between neuropsychological outcome following mild head injury (MHI) and APOE genotype. Methods: Data from a population-based longitudinal study (n = 3,500) were used to identify 34 adults who experienced MHI during the course of the study. Their pre- and postinjury performances on a battery of nine neuropsychological tests were compared within person, and the postinjury performance was compared with that of age- and gender-matched control subjects. Results: The within-person comparisons showed that participants with at least oneAPOE ε4 allele (n = 11) had a significantly decreased postinjury performance on three of the tests, whereas the postinjury performance for APOE ε4-negative participants (n = 23) was unchanged. There was no significant difference in postinjury performance between participants with/without the ε4 allele, and neither group was impaired relative to controls. Conclusions: APOE genotype may influence the outcome following an MHI. Pre/postinjury within-person comparisons seem more sensitive than control group comparisons for detecting injury-related effects.
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- ref (ämneskategori)
- art (ämneskategori)
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