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A randomized, dose-...
A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
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- Nilsson, S. (författare)
- Karolinska Institutet
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- Strang, P. (författare)
- Karolinska Institutet
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Aksnes, A. K. (författare)
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- Franzen, Lars (författare)
- Umeå universitet,Onkologi
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Olivier, P. (författare)
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Pecking, A. (författare)
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Staffurth, J. (författare)
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Vasanthan, S. (författare)
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Andersson, C. (författare)
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Bruland, O. S. (författare)
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(creator_code:org_t)
- Oxford : Elsevier, 2012
- 2012
- Engelska.
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Ingår i: European Journal of Cancer. - Oxford : Elsevier. - 0959-8049 .- 1879-0852. ; 48:5, s. 678-686
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: To investigate the dose-response relationship and pain-relieving effect of radium-223, a highly bone-targeted alpha-pharmaceutical. Methods: One hundred patients with castration-resistant prostate cancer (CRPC) and painful bone metastases were randomized to a single intravenous dose of 5, 25, 50 or 100 kBq/kg radium-223. The primary end-point was pain index (visual analogue scale [VAS] and analgesic use), also used to classify patients as responders or non-responders. Results: A significant dose response for pain index was seen at week 2 (P = .035). At week 8 there were 40%, 63%, 56% and 71% pain responders (reduced pain and stable analgesic consumption) in the 5, 25, 50 and 100 kBq/kg groups, respectively. On the daily VAS, at week 8, pain decreased by a mean of -30, -31, -27 and -28 mm, respectively (P = .008, P = .0005, P = .002, and P < .0001) in these responders (post-hoc analysis). There was also a significant improvement in the brief pain inventory functional index for all dose-groups (P = .04, .01, .002 and .02, Wilcoxon signed rank test). Furthermore, a decrease in bone alkaline phosphatase in the highest dose-group was demonstrated (P = .0067). All doses were safe and well tolerated. Conclusion: Pain response was seen in up to 71% of the patients with a dose response observed 2 weeks after administration. The highly tolerable side-effect profile of radium-223 previously reported was confirmed. (C) 2012 Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Pain
- Bone metastases
- Prostate cancer
- Castration-resistant
- Alpha-pharmaceutical
- Radium
- Alpharadin
- BPI
- Functional index
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nilsson, S.
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Strang, P.
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Aksnes, A. K.
-
Franzen, Lars
-
Olivier, P.
-
Pecking, A.
-
visa fler...
-
Staffurth, J.
-
Vasanthan, S.
-
Andersson, C.
-
Bruland, O. S.
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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European Journal ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet