Regional cyclin D1 overexpression or hypoxia correlate inversely with heterogeneous oestrogen receptor-alpha expression in human breast cancer.

• Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients were investigated by the use of antisera against SP and the neurokinin-1 receptor (NK-1R) and staining for demonstration of eosinophils. The degrees of SP innervation and NK-1R immunoreaction, as well as the levels of eosinophil infiltration, varied between different patients. Interestingly, NK-1R immunoreaction in the epithelium was often seen to be the most marked where there were numerous eosinophils in the underlying mucosa and where the mucosa showed a marked morphologic derangement. The observations suggest that there are marked fluctuations in effects of SP and eosinophils during the disease. The infiltrating eosinophils may be involved in the destruction of the mucosal tissue. Furthermore, for the majority of cases where there is marked derangement of the mucosa, it is apparent that there is an upregulation of the NK-1 receptor in the epithelium in parallel with the infiltration of the eosinophils.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Aged

Blotting; Western

Breast Neoplasms/genetics/*metabolism/pathology

Carcinoma/genetics/*metabolism/secondary

Cell Hypoxia

Cell Line; Tumor

Cyclin D1/genetics/*metabolism

Down-Regulation

Estrogen Receptor alpha

Female

Gene Amplification

Gene Expression Regulation; Neoplastic

Humans

Hypoxia-Inducible Factor 1; alpha Subunit

Immunohistochemistry

In Situ Hybridization; Fluorescence

Middle Aged

Neoplasm Staging

Receptors; Estrogen/genetics/*metabolism

Transcription Factors/genetics/metabolism

Tumor Markers; Biological/metabolism

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)