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Chylomicron/chylomicron remnant turnover in humans : evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants.

Karpe, F (författare)
Karolinska Institutet
Olivecrona, T (författare)
Umeå universitet,Fysiologisk kemi
Hamsten, A (författare)
Karolinska Institutet
visa fler...
Hultin, M (författare)
Umeå universitet,Fysiologisk kemi
visa färre...
 (creator_code:org_t)
1997
1997
Engelska.
Ingår i: Journal of Lipid Research. - 0022-2275 .- 1539-7262. ; 38:5, s. 949-61
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The size of cholesterol-rich lipoprotein particles is a strong determinant of whether they may be deposited in the arterial wall and by this become potentially atherogenic. This study deals with the in vivo transformation of larger-sized chylomicrons and chylomicron remnants to smaller-sized remnants. Twelve healthy men aged 22 to 45 years were given a fatty meal to which retinyl palmitate (RP) had been added. Plasmapheresis was performed 4 1/2 h after meal intake to isolate approximately 400 ml plasma. The RP-rich plasma was re-injected to the subject 24 h later. The RP content was determined in whole plasma and in Svedberg flotation rate fractions (Sf) > 400, Sf 60-400 and Sf 20-60. A compartmental model was developed for the kinetic analysis. Lipoprotein fractions showed minimal signs of aggregation, thus arguing for well-preserved postprandial lipoproteins. Approximately a fourth [23% (4-68%)] of the RP-containing lipoproteins in the Sf > 400 pool was converted to smaller species (Sf 60-400). Conversion of material from the Sf 60-400 to the Sf 20-60 fraction could not be detected. In a second study a large bolus dose of a triglyceride emulsion (Intralipid) was injected to subjects shortly after the RP-labeled plasma to investigate the endothelial binding of the chylomicron/chylomicron remnants. RP material in the Sf > 400 fraction rapidly returned to plasma, arguing for margination of chylomicrons, whereas the corresponding effect was minimal in the Sf 60-400 and Sf 20-60 fractions. The formation of small chylomicron remnants from the larger chylomicron/chylomicron remnant species is limited and large chylomicron/chylomicron remnants are not evenly distributed in plasma, rather they show signs of being marginated to the vascular endothelium.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

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Av författaren/redakt...
Karpe, F
Olivecrona, T
Hamsten, A
Hultin, M
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
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Journal of Lipid ...
Av lärosätet
Umeå universitet
Karolinska Institutet

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