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pNfH is a promising...
pNfH is a promising biomarker for ALS
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Ganesalingam, Jeban (författare)
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An, Jiyan (författare)
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Bowser, Robert (författare)
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- Andersen, Peter M (författare)
- Umeå universitet,Klinisk neurovetenskap
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Shaw, Christopher E. (författare)
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(creator_code:org_t)
- 2012-10-22
- 2013
- Engelska.
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Ingår i: Amytrophic Lateral Sclerosis and Frontotemporal degeneration. - : Informa Healthcare. - 2167-8421 .- 2167-9223. ; 14:2, s. 146-149
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- A diagnostic biomarker for ALS would permit early intervention with disease-modifying therapies while a biomarker for disease activity could accelerate the pace of drug discovery by facilitating shorter, and less costly, drug trials to be conducted with a smaller number of patients. Neurofilaments are the most abundant neuronal cytoskeletal protein. We set out to determine whether pNfH was a credible biomarker for ALS. pNfH levels were determined using an ELISA for 150 ALS subjects and 140 controls. We demonstrated a seven-fold elevation in the cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy subunit (pNfH) in ALS (median n = 2787 pg/ml, n = 150), compared to headache and other benign controls (3 (4 pg/ml, n = 100, p = < 0.05). There was a 10-fold elevation of pNfH compared to ALS mimics (266 pg/ml, n = 20) and other neurodegenerative and inflammatory conditions (27 (pg/ml for n = 20) which was also highly significant (p = < 0.05). pNfH achieved a diagnostic sensitivity of 90% and specificity of 87% in distinguishing ALS from all controls. We also detected an inverse correlation between CSF pNfH levels and disease duration (time from symptom onset to death, r(2) = 0.1247, p = 0.001). In conclusion, pNfH represents a promising candidate for inclusion in a panel of diagnostic and prognostic biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Neurofilament heavy chain
- biomarker
- amyotrophic lateral sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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