Decrease in binding for the neuropeptide VIP in response to marked inflammation of the mucosa in ulcerative colitis

• The neuropeptide vasoactive intestinal peptide (VIP) is involved in the neuroimmunomodulation of the intestine. In the present study, specimens from the sigmoid colon of ulcerative colitis (UC) and non-UC patients were examined for immunohistochemistry and in vitro receptor autoradiography. Marked occurrence of VIP binding was observed in the mucosa. However, there were very low levels of binding in areas showing pronounced inflammation/derangement. The study shows that marked derangement of the mucosa leads to a distinct decrease in VIP binding. Thus, it is possible that a decrease in trophic and anti-inflammatory VIP effects occurs in areas exhibiting a very marked inflammation.

Nyckelord

adult

aged

aged; 80 and over

autoradiography

biological markers

colitis

ulcerative/metabolism/pathology

female

gastric mucosa/metabolism/pathology

humans

immunohistochemistry

inflammation/metabolism/pathology

intestinal mucosa/metabolism/pathology

male

middle aged

receptors

vasoactive intestinal peptide/metabolism

vasoactive intestinal peptide/metabolism

Publikations- och innehållstyp

vet (ämneskategori)

art (ämneskategori)