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An improved synthes...
An improved synthesis of a galactosylated hydroxylysine building block and its use in solid-phase glycopeptide synthesis
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- Holm, Björn (författare)
- Umeå universitet,Kemiska institutionen
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- Broddefalk, Johan (författare)
- Umeå universitet,Kemiska institutionen
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- Flodell, Sara (författare)
- Umeå universitet,Kemiska institutionen
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- Wellner, Eric (författare)
- Umeå universitet,Kemiska institutionen
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- Kihlberg, Jan (författare)
- Umeå universitet,Kemiska institutionen
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visa färre...
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Tetrahedron. ; 56, s. 1579-86
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Different protective groups for (5R)-5-hydroxy-L-lysine were investigated in silver silicate promoted glycosylations with aceto-bromogalactose as glycosyl donor. Best results were obtained with Fmoc-Hyl(Cbz)-OAll, which was glycosylated in 80% yield. Removal of the allyl group gave a beta-D-galactosylated building block which was used in solid-phase synthesis of a glycopeptide from type II collagen. Such glycopeptides are required for studies of rheumatoid arthritis in a mouse that is transgenic for HLA-DR4, i.e. the class ii MHC molecule associated with rheumatism in humans.
Nyckelord
- glycosylation
- glycopeptides
- solid-phase synthesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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