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Association between...
Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease
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Chan, SSM (författare)
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Luben, R (författare)
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Olsen, A (författare)
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visa fler...
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Tjonneland, A (författare)
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Kaaks, R (författare)
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- Lindgren, Stefan (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Grip, Olof (författare)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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Bergmann, MM (författare)
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Boeing, H (författare)
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Karling, Pontus (författare)
- Umeå universitet,Medicin
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Overvad, K (författare)
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Veno, SK (författare)
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van Schaik, F (författare)
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Bueno-de-Mesquita, B (författare)
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Oldenburg, B (författare)
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Khaw, K-T (författare)
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Riboli, E (författare)
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Hart, AR (författare)
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visa färre...
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(creator_code:org_t)
- 2014-02-24
- 2014
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley-Blackwell. - 0269-2813 .- 1365-2036. ; 39:8, s. 834-842
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).Aim To conduct a prospective study to investigate the association between increased intake of DHA and risk of CD.Methods Overall, 229702 participants were recruited from nine European centres between 1991 and 1998. At recruitment, dietary intakes of DHA and fatty acids were measured using validated food frequency questionnaires. The cohort was monitored through to June 2004 to identify participants who developed incident CD. In a nested case-control analysis, each case was matched with four controls; odds ratios (ORs) were calculated for quintiles of DHA intake, adjusted for total energy intake, smoking, other dietary fatty acids, dietary vitamin D and body mass index.Results Seventy-three participants developed incident CD. All higher quintiles of DHA intake were inversely associated with development of CD; the highest quintile had the greatest effect size (OR=0.07; 95% CI=0.02-0.81). The OR trend across quintiles of DHA was 0.54 (95% CI=0.30-0.99, P-trend=0.04). Including BMI in the multivariate analysis, due to its correlation with dietary fat showed similar associations. There were no associations with the other dietary fatty acids studied.Conclusion There were inverse associations, with a biological gradient between increasing dietary docosahexaenoic acid intakes and incident Crohn's disease. Further studies in other populations should measure docosahexaenoic acid to determine if the association is consistent and the hypothesis tested in randomised controlled trials of purely docosahexaenoic acid supplementation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- infrared-spectroscopy; wood; lignin; chemistry; carbohydrate; pretreatment; hydrolysis; biomass; nmr
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Chan, SSM
-
Luben, R
-
Olsen, A
-
Tjonneland, A
-
Kaaks, R
-
Lindgren, Stefan
-
visa fler...
-
Grip, Olof
-
Bergmann, MM
-
Boeing, H
-
Hallmans, Göran
-
Karling, Pontus
-
Overvad, K
-
Veno, SK
-
van Schaik, F
-
Bueno-de-Mesquit ...
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Oldenburg, B
-
Khaw, K-T
-
Riboli, E
-
Hart, AR
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Alimentary Pharm ...
- Av lärosätet
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Umeå universitet
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Lunds universitet