Sökning: id:"swepub:oai:DiVA.org:umu-91869" >
DNA methylome profi...
DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns
-
Lokk, Kaie (författare)
-
Modhukur, Vijayachitra (författare)
-
Rajashekar, Balaji (författare)
-
visa fler...
-
Märtens, Kaspar (författare)
-
Mägi, Reedik (författare)
-
Kolde, Raivo (författare)
-
Koltšina, Marina (författare)
-
- Nilsson, Torbjörn K (författare)
- Umeå universitet,Klinisk kemi
-
Vilo, Jaak (författare)
-
Salumets, Andres (författare)
-
Tõnisson, Neeme (författare)
-
visa färre...
-
(creator_code:org_t)
- 2014-04-01
- 2014
- Engelska.
-
Ingår i: Genome Biology. - : BioMed Central. - 1465-6906 .- 1474-760X. ; 15:4, s. r54-
- Relaterad länk:
-
https://umu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://genomebiolog...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: DNA epigenetic modifications, such as methylation, are important regulators of tissue differentiation, contributing to processes of both development and cancer. Profiling the tissue-specific DNA methylome patterns will provide novel insights into normal and pathogenic mechanisms, as well as help in future epigenetic therapies. In this study, 17 somatic tissues from four autopsied humans were subjected to functional genome analysis using the Illumina Infinium HumanMethylation450 BeadChip, covering 486 428 CpG sites. RESULTS: Only 2% of the CpGs analyzed are hypermethylated in all 17 tissue specimens; these permanently methylated CpG sites are located predominantly in gene-body regions. In contrast, 15% of the CpGs are hypomethylated in all specimens and are primarily located in regions proximal to transcription start sites. A vast number of tissue-specific differentially methylated regions are identified and considered likely mediators of tissue-specific gene regulatory mechanisms since the hypomethylated regions are closely related to known functions of the corresponding tissue. Finally, a clear inverse correlation is observed between promoter methylation within CpG islands and gene expression data obtained from publicly available databases. CONCLUSIONS: This genome-wide methylation profiling study identified tissue-specific differentially methylated regions in 17 human somatic tissues. Many of the genes corresponding to these differentially methylated regions contribute to tissue-specific functions. Future studies may use these data as a reference to identify markers of perturbed differentiation and disease-related pathogenic mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Lokk, Kaie
-
Modhukur, Vijaya ...
-
Rajashekar, Bala ...
-
Märtens, Kaspar
-
Mägi, Reedik
-
Kolde, Raivo
-
visa fler...
-
Koltšina, Marina
-
Nilsson, Torbjör ...
-
Vilo, Jaak
-
Salumets, Andres
-
Tõnisson, Neeme
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Genome Biology
- Av lärosätet
-
Umeå universitet