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CSF and plasma oxyt...
CSF and plasma oxytocin levels in suicide attempters, the role of childhood trauma and revictimization
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- Chatzittofis, Andreas (författare)
- Karolinska Institutet
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- Nordström, Peter (författare)
- Karolinska Institutet
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- Uvnäs-Moberg, Kerstin (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health
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- Åsberg, Marie (författare)
- Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden
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- Jokinen, Jussi (författare)
- Karolinska Institutet,Umeå universitet,Psykiatri,Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden
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(creator_code:org_t)
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- Maghira and Maas Publications, 2014
- 2014
- Engelska.
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Ingår i: Neuro - endocrinology letters. - : Maghira and Maas Publications. - 0172-780X. ; 35:3, s. 213-217
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Some studies have reported an inverse relationship between childhood adversity and oxytocin levels. The purpose of this study was to assess the relationship between CSF and plasma oxytocin levels and lifetime trauma history in suicide attempters. We hypothesised lower CSF and plasma oxytocin levels in suicide attempters with high exposure to interpersonal violence and negative childhood emotional climate.METHODS: 28 medication free suicide attempters participated in the study. CSF and plasma morning basal levels of oxytocin were assessed with specific radio-immunoassays. The Karolinska Interpersonal Violence Scale (KIVS) was used to elicit lifetime trauma history and revictimization status and the childhood emotional climate factor was derived from the socialization subscale of the Karolinska Scales of Personality.RESULTS: Correlations between exposure to interpersonal violence as a child and as an adult and CSF and plasma oxytocin levels were not significant. Revictimized suicide attempters had significantly lower plasma oxytocin levels and more negative childhood emotional climate compared to non-revictimized suicide attempters.CONCLUSIONS: Our results indicate a complex relationship between life time trauma and the oxytocin system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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