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αβT Cell Receptors ...
αβT Cell Receptors Expressed by CD4(-)CD8αβ(-) Intraepithelial T Cells Drive Their Fate into a Unique Lineage with Unusual MHC Reactivities
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- Mayans, Sofia, 1976- (author)
- Umeå universitet,Immunologi/immunkemi,Sofia Mayans
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Stepniak, Dariusz (author)
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Palida, Sakina F (author)
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Larange, Alexandre (author)
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Dreux, Joanna (author)
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Arlian, Britni M (author)
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Shinnakasu, Ryo (author)
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Kronenberg, Mitchell (author)
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Cheroutre, Hilde (author)
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Lambolez, Florence (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Immunity. - : Elsevier BV. - 1074-7613 .- 1097-4180. ; 41:2, s. 207-218
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Coreceptor CD4 and CD8αβ double-negative (DN) TCRαβ(+) intraepithelial T cells, although numerous, have been greatly overlooked and their contribution to the immune response is not known. Here we used T cell receptor (TCR) sequencing of single cells combined with retrogenic expression of TCRs to study the fate and the major histocompatibility complex (MHC) restriction of DN TCRαβ(+) intraepithelial T cells. The data show that commitment of thymic precursors to the DN TCRαβ(+) lineage is imprinted by their TCR specificity. Moreover, the TCRs they express display a diverse and unusual pattern of MHC restriction that is nonoverlapping with that of CD4(+) or CD8αβ(+) T cells, indicating that they sense antigens that are not recognized by the conventional T cell subsets. The new insights indicate that DN TCRαβ(+) T cells form a third lineage of TCRαβ T lymphocytes expressing a variable TCR repertoire, which serve nonredundant immune functions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- ref (subject category)
- art (subject category)
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Immunity
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- By the author/editor
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Mayans, Sofia, 1 ...
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Stepniak, Darius ...
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Palida, Sakina F
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Larange, Alexand ...
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Dreux, Joanna
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Arlian, Britni M
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show more...
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Shinnakasu, Ryo
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Kronenberg, Mitc ...
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Cheroutre, Hilde
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Lambolez, Floren ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Immunity
- By the university
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Umeå University