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Combining conventio...
Combining conventional and stroma-derived tumour markers in pancreatic ductal adenocarcinoma
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- Franklin, Oskar (författare)
- Umeå universitet,Kirurgi
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- Öhlund, Daniel (författare)
- Umeå universitet,Kirurgi
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- Lundin, Christina (författare)
- Umeå universitet,Kirurgi
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- Öman, Mikael (författare)
- Umeå universitet,Kirurgi
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- Naredi, Peter (författare)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Wang, Wanzhong (författare)
- Umeå universitet,Patologi
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- Sund, Malin, 1972- (författare)
- Umeå universitet,Kirurgi
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(creator_code:org_t)
- IOS Press, 2015
- 2015
- Engelska.
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Ingår i: Cancer Biomarkers. - : IOS Press. - 1574-0153. ; 15:1, s. 1-10
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A lack of disease-specific symptoms and good tumour markers makes early detection and diagnosis of pancreatic ductal adenocarcinoma (PDAC) challenging. OBJECTIVE: To analyse the tissue expression and circulating levels of four stroma-derived substances (type IV collagen, endostatin/type XVIII collagen, osteopontin and tenascin C) and four conventional tumour markers (CA 19-9, TPS, CEA and Ca 125) in a PDAC cohort.METHODS: Tissue expression of markers in normal pancreas and PDAC tissue was analysed with immunofluorescence. Plasma concentrations of markers were measured before and after surgery. Patients with non-malignant disorders served as controls.RESULTS: The conventional and stromal substances were expressed in the cancer cell compartment and the stroma, respectively. Although most patients had increased levels of many markers before surgery, 2/12 (17%) of patients had normal levels of Ca 19-9 at this stage. High preoperative endostatin/type XVIII collagen, and postoperative type IV collagen was associated with short survival. Neither the pre-nor postoperative levels of TPS, Ca 125 or CA 19-9 were associated to survival.CONCLUSIONS: PDAC is characterized by an abundant stroma. These initial observations indicate that the stroma can be a source of PDAC tumour markers that are found in different compartments of the cancer, thus reflecting different aspects of tumour biology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Pancreatic ductal adenocarcinoma (PDAC)
- tumour markers
- stroma
- type IV collagen
- type XVIII llagen
- endostatin
- osteopontin
- tenascin C
- TPS
- Ca 125
- Ca 19-9
- CEA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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