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Early pregnancy sex...
Early pregnancy sex steroids and maternal risk of epithelial ovarian cancer
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- Schock, Helena, 1984- (författare)
- Umeå universitet,Patologi,Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
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- Surcel, Helja-Marja (författare)
- Oulu, Finland
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- Zeleniuch-Jacquotte, Anne (författare)
- Umeå universitet,Enheten för biobanksforskning,New York, USA
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- Grankvist, Kjell, 1954- (författare)
- Umeå universitet,Klinisk kemi
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- Lakso, Hans-Åke, 1962- (författare)
- Umeå universitet,Klinisk kemi
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- Fortner, Renee Turzanski (författare)
- Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- Heidelberg, Germany
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- Pukkala, Eero (författare)
- Helsinki, Finland; Tampere, Finland
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- Lehtinen, Matti (författare)
- Tampere, Finland
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- Toniolo, Paolo (författare)
- New York, USA; Lausanne, Switzerland
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- Lundin, Eva, 1955- (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- Society for Endocrinology, 2014
- 2014
- Engelska.
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Ingår i: Endocrine-Related Cancer. - : Society for Endocrinology. - 1351-0088 .- 1479-6821. ; 21:6, s. 831-844
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Well-established associations between reproductive characteristics and epithelial ovarian cancer (EOC) support an involvement of sex steroid hormones in the etiology of EOC. Limited previous studies have evaluated circulating androgens and the risk of EOC, and estrogens and progesterone have been investigated in only one of the previous studies. Furthermore, there is little data on potential heterogeneity in the association between circulating hormones and EOC by histological subgroup. Therefore, we conducted a nested case-control study within the Finnish Maternity Cohort and the Northern Sweden Maternity Cohort to investigate the associations between circulating pre-diagnostic sex steroid concentrations and the histological subtypes of EOC. We identified 1052 EOC cases among cohort members diagnosed after recruitment (1975-2008) and before March 2011. Up to three controls were individually matched to each case (n=2694). Testosterone, androstenedione, 17-hydroxyprogesterone (17-OHP), progesterone, estradiol (E-2), and sex hormone-binding globulin levels were measured in serum samples collected during the last pregnancy before EOC diagnosis. We used conditional logistic regression to estimate odds ratios (ORs) and 95% CIs. Associations between hormones and EOC differed with respect to tumor histology and invasiveness. Sex steroid concentrations were not associated with invasive serous tumors; however, doubling of testosterone and 17-OHP concentration was associated with approximately 40% increased risk of borderline serous tumors. A doubling of androgen concentrations was associated with a 50% increased risk of mucinous tumors. The risk of endometrioid tumors increased with higher E-2 concentrations (OR: 1.89 (1.20-2.98)). This large prospective study in pregnant women supports a role of sex steroid hormones in the etiology of EOC arising in the ovaries.
Ämnesord
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- prospective study
- case-control study
- pregnancy
- sex steroids
- ovarian neoplasms
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Schock, Helena, ...
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Surcel, Helja-Ma ...
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Zeleniuch-Jacquo ...
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Grankvist, Kjell ...
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Lakso, Hans-Åke, ...
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Fortner, Renee T ...
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visa fler...
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Kaaks, Rudolf
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Pukkala, Eero
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Lehtinen, Matti
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Toniolo, Paolo
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Lundin, Eva, 195 ...
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visa färre...
- Om ämnet
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Veterinärmedicin
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och Medicinsk biovet ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Endocrine-Relate ...
- Av lärosätet
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Umeå universitet