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Omega-3 fatty acid ...
Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease : the omega-3 Alzheimer's disease study
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- Irving, Gerd Faxén (författare)
- Karolinska Institutet
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- Freund-Levi, Yvonne, 1956- (författare)
- Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
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- Eriksdotter-Jönhagen, Maria (författare)
- Karolinska Institutet
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- Basun, Hans (författare)
- Uppsala universitet,Geriatrik,Divisions of Geriatrics, Uppsala University Hospital, Uppsala, Sweden
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- Brismar, Kerstin (författare)
- Karolinska Institutet
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- Hjorth, Erik (författare)
- Karolinska Institutet
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- Palmblad, Jan (författare)
- Karolinska Institutet
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- Vessby, Bengt (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden
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- Vedin, Inger (författare)
- Karolinska Institutet
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- Wahlund, Lars-Olof (författare)
- Karolinska Institutet
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- Cederholm, Tommy (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Department of Medicine, Karolinska University, Hospital, Huddinge, Stockholm, Sweden
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: Journal of The American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 57:1, s. 11-17
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Omega-3 fatty acids
- weight gain
- Alzheimer's disease
- dementia
- appetite
- nutrition
- APOE
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Irving, Gerd Fax ...
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Freund-Levi, Yvo ...
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Eriksdotter-Jönh ...
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Basun, Hans
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Brismar, Kerstin
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Hjorth, Erik
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visa fler...
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Palmblad, Jan
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Vessby, Bengt
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Vedin, Inger
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Wahlund, Lars-Ol ...
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Cederholm, Tommy
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
- Artiklar i publikationen
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Journal of The A ...
- Av lärosätet
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Uppsala universitet
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Örebro universitet
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Karolinska Institutet