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Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease : the omega-3 Alzheimer's disease study

Irving, Gerd Faxén (författare)
Karolinska Institutet
Freund-Levi, Yvonne, 1956- (författare)
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
Eriksdotter-Jönhagen, Maria (författare)
Karolinska Institutet
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Basun, Hans (författare)
Uppsala universitet,Geriatrik,Divisions of Geriatrics, Uppsala University Hospital, Uppsala, Sweden
Brismar, Kerstin (författare)
Karolinska Institutet
Hjorth, Erik (författare)
Karolinska Institutet
Palmblad, Jan (författare)
Karolinska Institutet
Vessby, Bengt (författare)
Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden
Vedin, Inger (författare)
Karolinska Institutet
Wahlund, Lars-Olof (författare)
Karolinska Institutet
Cederholm, Tommy (författare)
Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Department of Medicine, Karolinska University, Hospital, Huddinge, Stockholm, Sweden
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 (creator_code:org_t)
Wiley, 2009
2009
Engelska.
Ingår i: Journal of The American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 57:1, s. 11-17
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

Omega-3 fatty acids
weight gain
Alzheimer's disease
dementia
appetite
nutrition
APOE
MEDICINE
MEDICIN

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