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Proteomic identific...
Proteomic identification of p53-dependent protein phosphorylation
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- Rahman-Roblick, R. (författare)
- Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
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- Hellman, Ulf (författare)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Becker, S. (författare)
- Department of Oncology-Pathology, Karolinska Biomic Center, Karolinska Institutet, Stockholm, Sweden
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- Bader, F.G. (författare)
- Department of Surgery, University of Schleswig-Holstein, Lu¨beck, Germany
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- Auer, G. (författare)
- Karolinska Institutet
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- Wiman, K.G. (författare)
- Karolinska Institutet
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- Roblick, U.J. (författare)
- Department of Surgery, University of Schleswig-Holstein, Lu¨beck, Germany
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(creator_code:org_t)
- 2008-04-28
- 2008
- Engelska.
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Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 27:35, s. 4854-4859
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modifications may contribute to p53-mediated tumor suppression.
Nyckelord
- p53
- proteomics
- phosphorylation
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Oncogene
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