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Renal dysfunction i...
Renal dysfunction is a strong and independent risk factor for mortality and cardiovascular complications in renal transplantation
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- Fellström, Bengt, 1947- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Njurmedicin, The ALERT Study Group.
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- Jardine, Alan G. (författare)
- The ALERT Study Group
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- Soveri, Inga (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Njurmedicin, The ALERT Study Group
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Cole, E. (författare)
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- Neumayer, Hans-Helmutt (författare)
- The ALERT Study Group
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- Maes, Bart (författare)
- The ALERT Study Group
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- Gimpelewicz, Claudio (författare)
- The ALERT Study Group
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- Holdaas, Hallvard (författare)
- The ALERT Study Group
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 5:8, s. 1986-1991
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Renal transplant recipients (RTR) have shortened life expectancy, primarily due to premature cardiovascular disease (CVD). Traditional CVD risk factors are highly prevalent. In addition, several non-traditional risk factors may contribute to the high risk. The aim of the study was to evaluate the effects of renal dysfunction on mortality and cardiovascular complications in 1052 placebo-treated patients of the Assessment of LEscol in Renal Transplantation (ALERT) trial. Follow-up was 5-6 years and endpoints included cardiac death, non-cardiovascular death, all-cause mortality, major adverse cardiac event (MACE), non-fatal myocardial infarction (MI) and stroke. The effects of serum creatinine at baseline on these endpoints were evaluated. Elevated serum creatinine in RTR was a strong and independent risk factor for MACE, cardiac, non-cardiovascular, and all-cause mortality, but not for stroke or non-fatal MI alone. Serum creatinine was associated with increased mortality and MACE, independent of established CVD risk factors. Graft loss resulted in increased incidences of non-cardiovascular death, all-cause mortality, MACE and non-fatal MI. In conclusion, elevated serum creatinine is a strong risk factor for all-cause, non-cardiovascular and cardiac mortality, and MACE, independent of traditional risk factors, but not for stroke or non-fatal MI alone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Cardiovascular disease
- mortality
- renal transplant function
- risk factor
- Kidney diseases
- Njursjukdomar
- Medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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