Sökning: id:"swepub:oai:DiVA.org:uu-109379" >
Oligodendrocyte pro...
Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma
-
- Lindberg, Nanna, 1982- (författare)
- Uppsala universitet,Institutionen för genetik och patologi,Lene Uhrbom
-
- Kastemar, Marianne (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
- Olofsson, T (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
visa fler...
-
- Smits, Anja (författare)
- Uppsala universitet,Institutionen för neurovetenskap
-
- Uhrbom, Lene (författare)
- Uppsala universitet,Institutionen för genetik och patologi
-
visa färre...
-
(creator_code:org_t)
- 2009-04-27
- 2009
- Engelska.
-
Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 28:23, s. 2266-2275
- Relaterad länk:
-
http://www.nature.co...
-
visa fler...
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown. The recent identification of tumor-initiating cells in glioma, which share many similarities with normal neural stem cells, has suggested the cell of origin to be a transformed neural stem cell. In previous studies, using the RCAS/tv-a mouse model, platelet-derived growth factor B (PDGF-B)-induced gliomas have been generated from nestin or glial fibrillary acidic protein-expressing cells, markers of neural stem cells. To investigate if committed glial progenitor cells could be the cell of origin for glioma, we generated the Ctv-a mouse where tumor induction would be restricted to myelinating oligodendrocyte progenitor cells (OPCs) expressing 2',3'-cyclic nucleotide 3'-phosphodiesterase. We showed that PDGF-B transfer to OPCs could induce gliomas with an incidence of 33%. The majority of tumors resembled human WHO grade II oligodendroglioma based on close similarities in histopathology and expression of cellular markers. Thus, with the Ctv-a mouse we have showed that the cell of origin for glioma may be a committed glial progenitor cell.
Nyckelord
- glioma
- cell of origin
- neural stem cell
- oligodendrocyte progenitor cell
- glial cell
- PDGF
- MEDICINE
- MEDICIN
- Molekylär medicin
- Molecular Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Oncogene
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas