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The G-250A polymorp...
The G-250A polymorphism in the hepatic lipase gene promoter is associated with changes in hepatic lipase activity and LDL cholesterol : The KANWU Study
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Lindi, Virpi (författare)
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Schwab, Ursula (författare)
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Louheranta, Anne (författare)
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- Vessby, Bengt (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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Hermansen, Kjeld (författare)
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Tapsell, Linda (författare)
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Riccardi, Gabriele (författare)
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Rivellese, Angela A (författare)
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Laakso, Markku (författare)
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Uusitupa, Matti I J (författare)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 18:2, s. 88-95
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and aims: Hepatic lipase (HL) catalyzes the hydrolysis of triglycerides and phospholipids from lipoproteins, and promotes the hepatic uptake of tipoproteins. A common G-250A polymorphism in the promoter of the hepatic lipase gene (LIPC) has been described. The aim was to study the effects of the G-250A polymorphism on HL activity, serum lipid profile and insulin sensitivity. Methods and results: Altogether 151 healthy subjects (age 49 +/- 8 years, BMI 26.5 +/- 3.0 kg/m(2)) were randomly assigned for 3 months to an isoenergetic diet containing either a high proportion of saturated fatty acids (SFA diet) or monounsaturated fatty acids (MUFA diet). Within groups there was a second random assignment to supplements with fish oil (3.6 g n-3 FA/day) or placebo. At baseline, the A-250A genotype was associated with high serum LDL cholesterol concentration (P = 0.030 among three genotypes). On the MUFA diet carriers of the A-250A genotype presented a greater decrease in LDL cholesterol concentration than subjects with other genotypes (P = 0.007 among three genotypes). The rare -250A allele was related to Low HL activity (P < 0.001 among three genotypes). The diet did not affect the levels of HL activity among the genotypes. Conclusion: The A-250A genotype of the LIPC gene was associated with high LDL cholesterol concentration, but the MUFA-enriched diet reduced serum LDL cholesterol concentration especially in subjects with the A-250A genotype.
Nyckelord
- diet
- fat
- fish oil
- hepatic lipase
- lipoproteins
- polymorphism
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lindi, Virpi
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Schwab, Ursula
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Louheranta, Anne
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Vessby, Bengt
-
Hermansen, Kjeld
-
Tapsell, Linda
-
visa fler...
-
Riccardi, Gabrie ...
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Rivellese, Angel ...
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Laakso, Markku
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Uusitupa, Matti ...
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visa färre...
- Artiklar i publikationen
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NMCD. Nutrition ...
- Av lärosätet
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Uppsala universitet