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Cardiovascular dise...
Cardiovascular diseases and risk of hip fracture
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- Sennerby, Ulf (författare)
- Uppsala universitet,Ortopedi
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Gedeborg, Rolf (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Byberg, Liisa (författare)
- Uppsala universitet,Ortopedi
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- Garmo, Hans (författare)
- Regional Oncologic Center, Uppsala University, Uppsala
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- Ahlbom, Anders (författare)
- Karolinska Institutet
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- Pedersen, Nancy L. (författare)
- Karolinska Institutet
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- Michaëlsson, Karl (författare)
- Uppsala universitet,Ortopedi
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(creator_code:org_t)
- American Medical Association (AMA), 2009
- 2009
- Engelska.
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Ingår i: Journal of the American Medical Association (JAMA). - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 302:15, s. 1666-1673
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https://uu.diva-port... (primary) (Raw object)
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https://jamanetwork....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- CONTEXT: Recent studies indicate common etiologies for cardiovascular disease (CVD) and osteoporotic fractures. OBJECTIVES: To examine the relation between CVD and risk of hip fracture in twins and evaluate the relative importance of genetics and lifestyle factors in this association. DESIGN, SETTING, AND PARTICIPANTS: A cohort of all 31,936 Swedish twins born from 1914-1944 was followed up from the age of 50 years. The National Patient Registry identified twins with CVDs and fractures from 1964 through 2005. Time-dependent exposures using Cox proportional hazard regression models were evaluated. MAIN OUTCOME MEASURE: Time to hip fracture after diagnosis of CVD. RESULTS: The crude absolute rate of hip fractures was 12.6 per 1000 person-years after a diagnosis of heart failure, 12.6 per 1000 person-years after a stroke, 6.6 per 1000 person-years after a diagnosis of peripheral atherosclerosis, and 5.2 per 1000 person-years after a diagnosis of ischemic heart disease compared with 1.2 per 1000 person-years for those without a CVD diagnosis. The multivariable-adjusted hazard ratio (HR) of hip fracture after a diagnosis of heart failure was 4.40 (95% confidence interval [CI], 3.43-5.63); after a stroke, the HR was 5.09 (95% CI, 4.18-6.20); after a diagnosis of peripheral atherosclerosis, the HR was 3.20 (95% CI, 2.28-4.50); and after an ischemic heart disease event, the HR was 2.32 (95% CI, 1.91-2.84). Identical twins without heart failure and stroke also had, after their co-twins had been exposed to these respective diseases, an increased rate of hip fracture. These sibling twins pseudoexposed for heart failure had a multivariable-adjusted HR of 3.74 (95% CI, 1.97-7.10) for hip fracture, whereas pseudoexposure for stroke had an HR of 2.29 (95% CI, 1.20-4.35). CONCLUSIONS: A diagnosis of CVD was significantly associated with risk of subsequent hip fracture. Increased risks in co-twins without an index diagnosis suggest genetic factors in the association between CVD and osteoporotic fractures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Orthopaedics
- Ortopedi
- Orthopaedics
- Ortopedi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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