Sökning: id:"swepub:oai:DiVA.org:uu-11353" >
Effect of Rosuvasta...
Effect of Rosuvastatin on Outcomes in Chronic Haemodialysis Patients : Baseline Data from the AURORA Study
-
- Fellström, Bengt (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
-
Zannad, Faiez (författare)
-
Schmieder, Roland (författare)
-
visa fler...
-
Holdaas, Hallvard (författare)
-
Jardine, Alan G. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2007-07-31
- 2007
- Engelska.
-
Ingår i: Kidney and Blood Pressure Research. - : S. Karger AG. - 1420-4096 .- 1423-0143. ; 30:5, s. 314-322
- Relaterad länk:
-
https://www.karger.c...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD). Aims: AURORA (A study to evaluate the Use of Rosuvastatin in subjects On Regular haemodialysis: an Assessment of survival and cardiovascular events) is the first large-scale international trial to assess the effects of statins on cardiovascular outcomes in patients with ESRD on chronic haemodialysis. Preliminary baseline data from the randomised population are presented. Methods: A total of 2,775 patients from 280 centres in 25 countries were randomised into the study. Patients aged 50-80 years on regular chronic haemodialysis for at least 3 months before screening were eligible for inclusion. They were randomised 1:1 to receive either rosuvastatin 10 mg or placebo daily and assessed throughout the study. Results: The mean age at baseline was 64 years. Most patients were male (62%) and 85% were white. The median time since commencing renal replacement was 32 months. Mean total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were 4.53 mmol/l (175 mg/dl) and 2.57 mmol/l (99 mg/dl), respectively. Conclusion: Results from the AURORA trial will impact on the current guidelines and use of statins in this patient population.
Nyckelord
- Rosuvastatin
- End-stage renal disease
- Cardiovascular disease
- Haemodialysis
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas