Adipose tissue inflammation in polycystic ovary syndrome (PCOS)

• Context: Previous studies have indicated that peripheral circulating markers of inflammation are elevated in women with polycystic ovary syndrome (PCOS). Thus far, no studies concerning adipose tissue expression of inflammatory markers have been conducted in PCOS patients. Objectives: The aim of the study was to investigate if PCOS patients display increased adipose tissue expression of inflammatory markers. Design and Settings: Cross-sectional study at three out-patient gynecologic departments. Participants and Approach: Ten lean PCOS patients, 20 overweight PCOS patients, and 20 overweight controls underwent subcutaneous fat biopsies and blood samples. Main Outcome Measures: Adipose tissue gene expression of inflammatory markers, circulating markers of inflammation, and obesity-related metabolic disturbances. Results: Overweight PCOS patients had higher relative amounts of adipose tissue CCL2, CCR2, TNF-a, IL-18, CD14 and CD163 mRNA expression compared to lean PCOS women. There were no differences between overweight PCOS patients and overweight control subjects in this respect. Within the PCOS group, markers of adipose tissue inflammation correlated significantly with obesity-related metabolic disturbances, but when data were adjusted for age and BMI most correlations were lost. Conclusion: Overweight, rather than the PCOS diagnosis per se, appears to be the main explanatory variable for elevated adipose tissue inflammation in PCOS patients. Our findings suggest that lean PCOS patients carry less risk for metabolic complications later on in life.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Polycystic ovary syndrome

adipose tissue

inflammatory markers

metabolic syndrome

overweight

Obstetrics and women's diseases

Obstetrik och kvinnosjukdomar

Obstetrik och gynekologi

Obstetrics and Gynaecology

Publikations- och innehållstyp

vet (ämneskategori)

ovr (ämneskategori)