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Fibrinogen and hist...
Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia
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- Kårehed, Karin (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Wikström, Anna-Karin (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
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- Olsson, Anna-Karin (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Olovsson, Matts (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olvsson
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- Åkerud, Helena (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
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(creator_code:org_t)
- Wiley, 2010
- 2010
- Engelska.
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 89:1, s. 131-139
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN: The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining. SETTING: Uppsala University Hospital, Uppsala. METHODS: Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry. RESULTS: Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001). CONCLUSIONS: HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.
Nyckelord
- Angiogenesis
- coagulation
- fibrinogen
- histidine-rich glycoprotein
- preeclampsia
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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