Sökning: id:"swepub:oai:DiVA.org:uu-125800" >
Interim analysis of...
Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer
-
- Pettersson, D. (författare)
- Karolinska Institutet
-
Cedermark, B. (författare)
-
- Holm, T. (författare)
- Karolinska Institutet
-
visa fler...
-
- Radu, Calin (författare)
- Uppsala universitet,Enheten för onkologi
-
- Påhlman, Lars (författare)
- Uppsala universitet,Kolorektalkirurgi
-
- Glimelius, Bengt (författare)
- Karolinska Institutet,Uppsala universitet,Enheten för onkologi
-
- Martling, Anna (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2010-02-12
- 2010
- Engelska.
-
Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 97:4, s. 580-587
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: To address issues regarding the fractionation of radiotherapy (RT) and timing of surgery for rectal cancer, a multicentre trial has randomized patients to preoperative short-course RT with two different intervals to surgery, or long-course RT with delayed surgery. The present interim analysis assessed feasibility, compliance and complications after RT and surgery. METHODS: Some 303 patients were randomized to either short-course RT (5 x 5 Gy) and surgery within 1 week (group 1), short-course RT and surgery after 4-8 weeks (group 2) or long-course RT (25 x 2 Gy) and surgery after 4-8 weeks (group 3). RESULTS: Demographic data were similar between groups and there were few protocol violations (5.0-6 per cent). Eight patients (2.6 per cent) developed radiation-induced acute toxicity. There were no significant differences in postoperative complications between groups (46.6, 40.0 and 32 per cent in groups 1, 2 and 3 respectively; P = 0.164). Patients receiving short-course RT with surgery 11-17 days after the start of RT had the highest complication rate (24 of 37). CONCLUSION: Compliance was acceptable and severe acute toxicity was low, irrespective of fractionation. Short-course RT with immediate surgery had a tendency towards more postoperative complications, but only if surgery was delayed beyond 10 days after the start of RT. Registration number: NCT00904813 (http://www.clinicaltrials.gov).
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas