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Glomerular Transcri...
Glomerular Transcriptome Changes Associated with Lipopolysaccharide-Induced Proteinuria
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Sun, Ying (författare)
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He, Liqun (författare)
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Takemoto, Minoru (författare)
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- Patrakka, Jaakko (författare)
- Karolinska Institutet
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- Pikkarainen, Timo (författare)
- Karolinska Institutet
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- Genove, Guillem (författare)
- Karolinska Institutet
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Norlin, Jenny (författare)
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- Truvé, Katarina (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,SLU, Dept Anim Breeding & Genet
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- Tryggvason, Karl (författare)
- Karolinska Institutet
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- Betsholtz, Christer (författare)
- Karolinska Institutet
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(creator_code:org_t)
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- 2009-01-09
- 2009
- Engelska.
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Ingår i: American Journal of Nephrology. - : S. Karger AG. - 0250-8095 .- 1421-9670. ; 29:6, s. 558-570
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Global gene expression patterns have recently been characterized in normal glomeruli, but gene expression changes that accompany glomerular disease remain poorly characterized. Method: Here, we mapped global glomerular gene expression profile changes occurring in conjunction with lipopolysaccharide (LPS)-induced proteinuria in mice. Results: We observed dramatic transcriptional reprogramming in glomeruli in response to LPS, representing some 20% of all genes and about 45% of the genes that are normally highly expressed in glomeruli. Bioinformatic analysis revealed significant changes in transcripts encoding proteins involved in the regulation of adherence junctions, actin cytoskeleton and survival in podocytes. In the LPS-treated mice, we observed dysregulation of genes expressed in glomerular endothelial and mesangial cells and in podocytes, there was also a significant decrease in podocyte number. Moreover, collagen alpha 1, alpha 2 (IV) and laminin 10 (laminin alpha 5 beta 1 gamma 1), which are expressed in immature glomeruli, were upregulated in the glomeruli of LPS-treated mice, suggesting remodeling of the glomerular basement membrane and activation of mesangial cells. By superimposing the LPS-induced changes onto GlomNet, a protein-protein interaction network was predicted for podocyte proteins affected by LPS. Conclusions: The detected changes in glomerular gene expression and their involvement in protein interaction networks provide putative markers for early and transient glomerular injury and proteinuria. Copyright (c) 2009 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Glomerulus
- Proteinuria
- Microarray
- Lipopolysaccharide
- Gene expression
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Sun, Ying
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He, Liqun
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Takemoto, Minoru
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Patrakka, Jaakko
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Pikkarainen, Tim ...
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Genove, Guillem
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visa fler...
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Norlin, Jenny
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Truvé, Katarina
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Tryggvason, Karl
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Betsholtz, Chris ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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- Av lärosätet
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Uppsala universitet
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Sveriges Lantbruksuniversitet
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Karolinska Institutet