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Postsurgical inflam...
Postsurgical inflammatory response is not associated with increased serum cystatin C values
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- Åkerfeldt, Torbjörn (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,klinisk kemi
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- Helmersson, Johanna (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,biologisk struktur och funktion
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- Larsson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,biologisk struktur och funktion
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: Clinical Biochemistry. - : Elsevier BV. - 0009-9120 .- 1873-2933. ; 43:13-14, s. 1138-1140
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Cystatin C is used both as a glomerular filtration (GFR) marker and a cardiovascular risk marker. There are several studies showing an association between cystatin C and inflammatory markers and it has been suggested that the inflammatory response in itself could result in elevated cystatin C levels. The aim of this study was to evaluate if an induced inflammatory response has an effect on cystatin C levels in humans. MATERIALS AND METHODS: CRP and cystatin C were analyzed in serum samples from orthopedic surgery patients (n=29). The patients were sampled prior to surgery and four and thirty days after surgery. RESULTS: The surgery induced a pronounced CRP elevation on day four, median 137.3 (interquartile range 104.1-178.2) mg/L compared to 1.94 (1.20-8.70) mg/L before surgery, P<0.001, but no significant difference in cystatin C levels before and four and thirty days after surgery could be seen. CONCLUSIONS: The orthopedic surgery-induced inflammatory response does not cause changes in cystatin C levels.
Nyckelord
- Cystatin C
- C-reactive protein
- Glomerular filtration rate
- Human
- Inflammation
- Surgery
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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