Sökning: onr:"swepub:oai:DiVA.org:uu-139315" >
Arsenic methylation...
Arsenic methylation efficiency increases during the first trimester of pregnancy independent of folate status
-
- Gardner, Renee M. (författare)
- Karolinska Institutet
-
- Nermell, Barbro (författare)
- Karolinska Institutet
-
- Kippler, Maria (författare)
- Karolinska Institutet
-
visa fler...
-
- Grandér, Margaretha (författare)
- Karolinska Institutet
-
- Li, Li (författare)
- Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
-
- Ekström, Eva-Charlotte (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell kvinno- & mödrahälsovård/Essén
-
- Rahman, Anisur (författare)
- International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh
-
- Lönnerdal, Bo (författare)
- Department of Nutrition, University of California, USA
-
- Hoque, A. M. Waheedul (författare)
- International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh
-
- Vahter, Marie (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: Reproductive Toxicology. - : Elsevier BV. - 0890-6238 .- 1873-1708. ; 31:2, s. 210-218
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Exposure to inorganic arsenic during pregnancy may negatively influence the offspring, though efficient metabolism of arsenic to dimethylarsinic acid (DMA) likely reduces the health risks. This study aimed to evaluate methylation of arsenic over the entire pregnancy and the influence of nutritional status. We studied longitudinally the arsenic metabolite pattern in the urine of 324 pregnant women exposed to arsenic via drinking water and food in rural Bangladesh. Metabolism of arsenic to DMA increased markedly over the course of pregnancy, with the greatest improvement occurring in the first trimester, along with a marked decrease in the most risk-associated monomethylated metabolite. This improvement in methylation was not associated with nutritional status, including vitamin B(12) and folate. Efficient methylation to DMA was associated with improved urinary excretion of arsenic, relative to blood arsenic concentrations, indicating that micronutrient-independent up-regulation of arsenic metabolism already in early pregnancy may provide protection for the fetus.
Nyckelord
- Arsenic
- Metabolism
- Pregnancy
- Nutrition
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gardner, Renee M ...
-
Nermell, Barbro
-
Kippler, Maria
-
Grandér, Margare ...
-
Li, Li
-
Ekström, Eva-Cha ...
-
visa fler...
-
Rahman, Anisur
-
Lönnerdal, Bo
-
Hoque, A. M. Wah ...
-
Vahter, Marie
-
visa färre...
- Artiklar i publikationen
-
Reproductive Tox ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet