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Sökning: id:"swepub:oai:DiVA.org:uu-149332" > Obesity and Increas...

Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants

Jacobsson, Josefin A (författare)
Uppsala universitet,Funktionell farmakologi
Fredriksson, Robert (preses)
Uppsala universitet,Funktionell farmakologi
Schiöth, Helgi B (preses)
Uppsala universitet,Funktionell farmakologi
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Farooqi, Sadaf (opponent)
Cambridge Institute for Medical Research, Department of Clinical Biochemistry
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 (creator_code:org_t)
ISBN 9789155480394
Uppsala : Acta Universitatis Upsaliensis, 2011
Engelska 68 s.
Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 658
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
Stäng  
  • Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. These findings may also provide more rational approaches to therapy, either by identifying underlying causes or point out the need for different treatments. In addition, the timing and severity of obesity may provide insights into the aetiology of obesity and also identify age-specific determinants of weight gain. Recently, genome-wide association studies have led to a rapid progress in our understanding of the genetic basis of various diseases and candidate genes for obesity have been identified. The overall aim of this thesis was to investigate the genetic impact on severity of childhood obesity and the associations between obesity and genetic variants in the fat mass and obesity associated gene, FTO, and MGAT1, the gene encoding mannosyl (α-1,3-)-glycoprotein β-1,2-N-acetyl-glucosaminyltransferase. We show that the impact of parental body mass index (BMI) on the severity of obesity in children is strengthened as the child grows older, whereas the age at obesity onset is of limited importance. By association studies, we show that single nucleotide polymorphisms downstream MGAT1 influence susceptibility to obesity. Moreover, these variants affect the levels of unsaturated fatty acids and desaturase indices, variables previously shown to correlate with obesity. Furthermore, one variant in the first intronic region of FTO is associated with obesity among children but not with BMI or other measures of adiposity at older ages. However, this variant shows a weight-dependent association with cognitive function among elderly men. By direct sequencing, we identified novel variants in FTO, affecting glucose homeostasis in a BMI-independent manner. Furthermore, we found gender specific effects for FTO, both regarding obesity susceptibility and related phenotypes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

Obesity
BMI
SNP
haplotype
association study
FTO
MGAT1
Pharmacology
Farmakologi
Farmakologi
Pharmacology

Publikations- och innehållstyp

vet (ämneskategori)
dok (ämneskategori)

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