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Comparative PET ima...
Comparative PET imaging of experimental tumors with bromine-76-labeled antibodies, fluorine-18-fluorodeoxyglucose and carbon-11-methionine
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Lövqvist, Anna (författare)
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- Sundín, Anders (författare)
- Uppsala universitet,Enheten för radiologi
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Roberto, Amilcar (författare)
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visa fler...
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Carlsson, Jörgen (författare)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap
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- Lundqvist, Hans (författare)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap
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visa färre...
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Journal of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 38:7, s. 1029-1035
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The potential of a 76Br-labeled anti-carcinoembryonic antigen monoclonal antibody (MAb), 38S1, as tumor-imaging agent for PET was investigated in a comparative experimental study with [18F]fluorodeoxyglucose ([18F]FDG) and L-[methyl-11C]methionine ([11C]Met). METHODS: The three radiotracers were administered to nude rats carrying subcutaneous xenografts or liver metastases from a human colonic carcinoma. Tracer biodistribution was evaluated by PET imaging and radioactivity measurement of dissected tissues and also by whole-body autoradiography for subcutaneous xenografts. RESULTS: For PET imaging of subcutaneous tumors, 76Br-38S1 proved superior to the other radiotracers. Tumor-to-tissue ratios were, except for the tumor-to-blood ratio, generally higher for 76Br-labeled MAb than for [18F]FDG and [11C]Met. Liver metastases were imaged with PET using both 76Br-38S1 and [18F]FDG, and the metastases-to-liver ratios of dissected samples were not significantly different for the two radiotracers. CONCLUSION: The tumor-imaging capacity of 76Br-labeled MAb 38S1 was superior to [18F]FDG and [11C]Met in the subcutaneous tumor model, whereas 76Br-38S1 and [18F]FDG were equally successful for the identification of liver metastases.
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- art (ämneskategori)
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