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Cognitive outcome f...
Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression
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- Marklund, Niklas (author)
- Uppsala universitet,Neurokirurgi
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Bareyre, Florence M. (author)
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Royo, Nicolas C. (author)
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Thompson, Hilaire J. (author)
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Mir, Anis K. (author)
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Grady, Sean (author)
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Schwab, Martin E. (author)
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McIntosh, Tracy K. (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Journal of Neurosurgery. - 0022-3085 .- 1933-0693. ; 107:4, s. 844-853
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Object. Central nervous system axons regenerate poorly after traumatic brain injury (TBI), partly due to inhibitors such as the protein Nogo-A present in myelin. The authors evaluated the efficacy of anti-Nogo-A monoclonal antibody (mAb) 7B 12 administration on the neurobehavioral and cognitive outcome of rats following lateral fluid-percussion brain injury, characterized the penetration of the 7B 12 or control antibodies into target brain regions, and evaluated the effects of Nogo-A inhibition on hemispheric tissue loss and sprouting of uninjured motor tracts in the cervical cord. To elucidate a potential molecular response to Nogo-A inhibition, we evaluated the effects of 7B 12 on hippocampal GAP-43 expression. Methods. Beginning 24 hours after lateral fluid-percussion brain injury or sham injury in rats, the mAb 7B12 or control antibody was infused intracerebroventricularly over 14 days, and behavior was assessed over 4 weeks. Results. Immunoreactivity for 7B 12 or immunoglobulin G was detected in widespread brain regions at 1 and 3 weeks postinjury. The brain-injured animals treated with 7B12 showed improvement in cognitive function (p < 0.05) at 4 weeks but no improvement in neurological motor function from 1 to 4 weeks postinjury compared with brain-injured, vehicle-treated controls. The enhanced cognitive function following inhibition of Nogo-A was correlated with an attenuated postinjury downregulation of hippocampal GAP-43 expression (p < 0.05). Conclusions. Increased GAP-43 expression may be a novel molecular mechanism of the enhanced cognitive recovery mediated by Nogo-A inhibition after TBI in rats.
Keyword
- Nervous system diseases
- Regeneration
- Cognition
- Growth associated protein 43
- Hippocampus
- Treatment
- Encephalon
- Prognosis
- Head trauma
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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