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Emergency presentat...
Emergency presentation of colon cancer is most frequent during summer
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- Gunnarsson, H. (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i D län (CKFD)
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- Holm, T. (författare)
- Karolinska Institutet
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- Ekholm, A. (författare)
- Uppsala universitet,Centrum för klinisk forskning i D län (CKFD)
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- Olsson, L. I. (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i D län (CKFD)
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(creator_code:org_t)
- 2010-03-23
- 2011
- Engelska.
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Ingår i: Colorectal Disease. - : Wiley. - 1462-8910 .- 1463-1318. ; 13:6, s. 663-668
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aim: The frequency of emergency colon cancer (ECC) was determined using a reproducible definition of 'emergency' to analyse the impact of mode of presentation on long-term prognosis and to search for risk factors for an emergency presentation. Method: All patients with colon cancer treated at one Swedish GDH between 1996 and 2005 (N = 604) were eligible. Patients admitted through the emergency room, operated on within three days and with an emergency condition confirmed at surgery were classified as ECC. Survival was analysed by Kaplan-Meier estimates and risk of death by Cox regression. Results: The rate of ECC was 97/585 (17%). Patients with ECC were older (median 77 vs 74, P = 0.02), they had more stage III and IV cancers (65% vs 47%; chi 2 = 9.4, P < 0.001) and had a cancer located in the caecum less often (20% vs 33%, chi 2 = 4.3 P = 0.04). ECC were most frequent between June and August (36%), whereas elective cases were evenly distributed throughout the year (chi 2 = 7.8; P = 0.049), Crude 5-year survival was 18% in ECC and 38% in the elective group (P < 0.001). The hazard ratio for death within five years in ECC, with 30-day mortality excluded and adjusted for age and sex was 2.25 (95% CI; 1.42-3.55). Conclusion: Emergency presentation of colon cancer is an independent and adverse risk factor for long-term survival. The causes of a seasonal variation need to be clarified.
Nyckelord
- Colon cancer
- emergency
- stage
- population-based
- survival
- risk factors
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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