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Oncolytic Viruses f...
Oncolytic Viruses for the Treatment of Neuroendocrine Tumors
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- Essand, Magnus (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab,Essand
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- Leja, Justyna (författare)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab,Essand
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- Giandomenico, Valeria (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Onkologisk endokrinologi, Kjell Öberg
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- Öberg, Kjell E. (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Onkologisk endokrinologi, Kjell Öberg
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(creator_code:org_t)
- 2011-05-30
- 2011
- Engelska.
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Ingår i: Hormone and Metabolic Research. - : Georg Thieme Verlag KG. - 0018-5043 .- 1439-4286. ; 43:12, s. 877-883
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Oncolytic viruses are emerging as anticancer agents, and they have also shown great promise for use against neuroendocrine tumors. Many viruses have a natural tropism for replication in tumor cells. Others can be genetically engineered to selectively kill tumor cells. Viruses have some advantages as therapeutic agents over current cytotoxic drugs and small molecules. They replicate in tumor cells and thereby increase in number over time leading to increased dosage. They are immunogenic and can alter the immunosuppressive tumor microenvironment and activate immune effector cells. They have also been shown to be able to kill drug-resistant cancer stem cells. This article reviews the recent literature on oncolytic viruses used so far for neuroendocrine tumors and indicates important issues to focus on in the future.
Nyckelord
- virotherapy; oncolytic virus; neuroendocrine tumors
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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