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Rationale and study...
Rationale and study design of PROVHILO - a worldwide multicenter randomized controlled trial on protective ventilation during general anesthesia for open abdominal surgery
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Hemmes, Sabrine N. T. (författare)
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Severgnini, Paolo (författare)
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Jaber, Samir (författare)
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Canet, Jaume (författare)
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Wrigge, Hermann (författare)
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Hiesmayr, Michael (författare)
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Tschernko, Edda M. (författare)
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Hollmann, Markus W. (författare)
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Binnekade, Jan M. (författare)
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- Hedenstierna, Göran (författare)
- Uppsala universitet,Klinisk fysiologi
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Putensen, Christian (författare)
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de Abreu, Marcelo Gama (författare)
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Pelosi, Paolo (författare)
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Schultz, Marcus J. (författare)
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(creator_code:org_t)
- 2011-05-06
- 2011
- Engelska.
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 12, s. 111-
- Relaterad länk:
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https://trialsjourna...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Post-operative pulmonary complications add to the morbidity and mortality of surgical patients, in particular after general anesthesia >2 hours for abdominal surgery. Whether a protective mechanical ventilation strategy with higher levels of positive end-expiratory pressure (PEEP) and repeated recruitment maneuvers; the "open lung strategy", protects against post-operative pulmonary complications is uncertain. The present study aims at comparing a protective mechanical ventilation strategy with a conventional mechanical ventilation strategy during general anesthesia for abdominal non-laparoscopic surgery. Methods: The PROtective Ventilation using HIgh versus LOw positive end-expiratory pressure ("PROVHILO") trial is a worldwide investigator-initiated multicenter randomized controlled two-arm study. Nine hundred patients scheduled for non-laparoscopic abdominal surgery at high or intermediate risk for post-operative pulmonary complications are randomized to mechanical ventilation with the level of PEEP at 12 cmH(2)O with recruitment maneuvers (the lung-protective strategy) or mechanical ventilation with the level of PEEP at maximum 2 cmH(2)O without recruitment maneuvers (the conventional strategy). The primary endpoint is any post-operative pulmonary complication. Discussion: The PROVHILO trial is the first randomized controlled trial powered to investigate whether an open lung mechanical ventilation strategy in short-term mechanical ventilation prevents against postoperative pulmonary complications.
Nyckelord
- MEDICINE
- MEDICIN
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Hemmes, Sabrine ...
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Severgnini, Paol ...
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Jaber, Samir
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Canet, Jaume
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Wrigge, Hermann
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Hiesmayr, Michae ...
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visa fler...
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Tschernko, Edda ...
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Hollmann, Markus ...
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Binnekade, Jan M ...
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Hedenstierna, Gö ...
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Putensen, Christ ...
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de Abreu, Marcel ...
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Pelosi, Paolo
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Schultz, Marcus ...
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Uppsala universitet