Sökning: id:"swepub:oai:DiVA.org:uu-156101" >
Relation between br...
Relation between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage
-
- Zetterling, Maria (författare)
- Uppsala universitet,Neurokirurgi
-
- Hillered, Lars (författare)
- Uppsala universitet,Neurokirurgi
-
- Enblad, Per (författare)
- Uppsala universitet,Neurokirurgi
-
visa fler...
-
- Karlsson, Torbjörn (författare)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Ronne-Engström, Elisabeth (författare)
- Uppsala universitet,Neurokirurgi
-
visa färre...
-
(creator_code:org_t)
- 2011
- 2011
- Engelska.
-
Ingår i: Journal of Neurosurgery. - 0022-3085 .- 1933-0693. ; 115:1, s. 66-74
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Object. The aim in the present investigation was to study the relation between brain interstitial and systemic blood glucose concentrations during the acute phase after subarachnoid hemorrhage (SAH). The authors also evaluated the effects of insulin administration on local brain energy metabolism. Methods. Nineteen patients with spontaneous SAH were prospectively monitored with intracerebral microdialysis (MD). The relation between plasma glucose and MD-measured interstitial brain glucose concentrations as well as the temporal pattern of MD glucose, lactate, pyruvate, glutamate, and glycerol was studied for 7 days after SAH. Using a target plasma glucose concentration of 5-10 mmol/L, the effect of insulin injection was also evaluated. Results. The mean (+/- SD) correlation coefficient between plasma glucose and MD glucose was 0.27 +/- 0.27 (p = 0.0005), with a high degree of individual variation. Microdialysis glucose, the MD/plasma glucose ratio, and MD glutamate concentrations decreased in parallel with a gradual increase in MD pyruvate and MD lactate concentrations. There were no significant changes in the MD L/P ratio or MD glycerol levels. Insulin administration induced a decrease in MD glucose and MD pyruvate. Conclusions. After SAH, there was a positive correlation between plasma and MD glucose concentrations with a high degree of individual variation. A gradual decline in MD glucose and the MD/plasma glucose ratio and an increase in MD pyruvate and MD lactate concentrations during the 1st week after SAH suggest a transition to a hyperglycolytic state with increased cerebral glucose consumption. The administration of insulin was related to a lowering of MD glucose and MD pyruvate, often to low levels even though plasma glucose values remained above 6 mmol/L. After SAH, the administration of insulin could impede the glucose supply of the brain.
Nyckelord
- brain glucose
- plasma glucose
- insulin
- microdialysis
- subarachnoid hemorrhage
- vascular disorders
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas