Sökning: id:"swepub:oai:DiVA.org:uu-160201" >
Dystrobrevin-bindin...
Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers
-
- Andreou, Dimitrios (författare)
- Karolinska Institutet
-
Saetre, Peter (författare)
-
- Kähler, Anna K. (författare)
- Karolinska Institutet
-
visa fler...
-
Werge, Thomas (författare)
-
Andreassen, Ole A. (författare)
-
- Agartz, Ingrid (författare)
- Karolinska Institutet
-
Sedvall, Göran C. (författare)
-
- Hall, Håkan (författare)
- Uppsala universitet,Geriatrik
-
- Terenius, Lars (författare)
- Karolinska Institutet
-
- Jönsson, Erik G. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 21:9, s. 700-704
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The dystrobrevin binding protein-1 (DTNBP1) gene encodes dysbindin-1, a protein involved in neurodevelopmental and neurochemical processes related mainly to the monoamine dopamine. We investigated possible associations between eleven DTNBP1 polymorphisms and cerebrospinal fluid (CSF) concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy human subjects (n=132). Two polymorphisms, rs2619538 and rs760666, were nominally associated with CSF HVA and 5-HIAA concentrations, whereas a third polymorphism, rs909706, showed association only with HVA. After correction for multiple testing only the associations between rs2619538 and HVA and 5-HIAA concentrations remained significant. No significant association was found between any of the investigated DTNBP1 polymorphisms and CSF MHPG concentrations. The results suggest that genetic variation in DTNBP1 gene affects the regulation of dopamine and serotonin turnover in the central nervous system of healthy volunteers.
Nyckelord
- Dystrobrevin-binding protein 1 gene (DTNBP1)
- Cerebrospinal fluid (CSF)
- 5-Hydroxyindoleacetic acid (5-HIAA)
- Homovanillic acid (HVA)
- 3-Methoxy-4-hydroxyphenylglycol (MHPG)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Andreou, Dimitri ...
-
Saetre, Peter
-
Kähler, Anna K.
-
Werge, Thomas
-
Andreassen, Ole ...
-
Agartz, Ingrid
-
visa fler...
-
Sedvall, Göran C ...
-
Hall, Håkan
-
Terenius, Lars
-
Jönsson, Erik G.
-
visa färre...
- Artiklar i publikationen
-
European Neurops ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet