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Polymorphic variati...
Polymorphic variations in the gene for osteoprotegerin are associated with bone mineral density and predict fractures in elderly men: Data from Mr OS Sweden. :
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- Penno, Hendrik, 1962- (författare)
- Uppsala universitet,Ortopedi
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- Grundberg, Elin (författare)
- The Wellcome Trust Sanger Institute, Hinxton, UK
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- Mallmin, Hans (författare)
- Uppsala universitet,Ortopedi
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visa fler...
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- Pastinen, Tomi (författare)
- Department of Human Genetics, McGill University and Genome Québec Innovation Centre, Montreal, QC, Canada
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- Ohlsson, Claes (författare)
- 4Center for Bone Research at the Sahlgrenska Academy, Department of Internal Medicine, Göteborg University, Gothenburg, Sweden
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- Mellström, Dan (författare)
- Department of Geriatric Medicine, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
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- Karlsson, Magnus K. (författare)
- Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Science, Lund University and Department of Orthopaedics, Skane University Hospital, Malmö, Sweden
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- Ljunggren, Östen (författare)
- Uppsala universitet,Medicin
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- Kindmark, Andreas (författare)
- Uppsala universitet,Medicin
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background: Osteoporosis is a polygenetic disorder where several genes are known to be involved. In this report we investigated the association between polymorphic variations in the gene for osteoprotegerin (OPG) and bone mineral density (BMD) and fragility fractures in elderly men. Methods: The study was performed in Mr OS Sweden, a cohort consisting of 3014 randomly selected men between 69 and 81 years of age, where at baseline BMD was measured at hip and spine by dual energy X ray absorbtiometry (DXA) and blood samples extracted. DNA was then isolated and the OPG gene was characterised. Prospective fractures, all verified by X-rays, were recorded for 5 years following baseline. Common variants in the 3’ and 5’UTR of the OPG gene was typed using Sequenom technology. Results: There was a significant association between common genetic variants in the gene for OPG and BMD at both hip (top SNP rs10955908, p<0.0008) and spine (top SNP rs10955908, p<0.0008) . The differences in BMD related to presence of various OPG alleles were between 0.5-3.5%. There was also an association with fragility fractures with odds ratio for rs6993813 reaching statistical significance (p=0.03) For five other SNPs were tested were the association with fractures did not reach statistical significance (p=0.12 - 0.19). Conclusion: Polymorphic variations in the gene for OPG are associated with BMD and fragility fractures in elderly men. The data support the view that variation in the OPG gene is a determinant for BMD and fragility fracture risk also in men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- osteoporosis
- osteoprotegerin
- bone mineral density
- fracture
- polymorphism
- Orthopaedics
- Ortopedi
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Penno, Hendrik, ...
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Grundberg, Elin
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Mallmin, Hans
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Pastinen, Tomi
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Ohlsson, Claes
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Mellström, Dan
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visa fler...
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Karlsson, Magnus ...
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Ljunggren, Östen
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Kindmark, Andrea ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Av lärosätet
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Uppsala universitet