Sökning: id:"swepub:oai:DiVA.org:uu-160998" >
Longitudinal MRI st...
Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder
-
Järnum, Hanna (författare)
-
Eskildsen, Simon F (författare)
-
Steffensen, Elena G (författare)
-
visa fler...
-
Lundbye-Christensen, Søren (författare)
-
Simonsen, Carsten W (författare)
-
Thomsen, Ib S (författare)
-
Fründ, Ernst-Torben (författare)
-
Théberge, Jean (författare)
-
- Larsson, Elna-Marie (författare)
- Uppsala universitet,Enheten för radiologi
-
visa färre...
-
(creator_code:org_t)
- 2011-09-16
- 2011
- Engelska.
-
Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 124:6, s. 435-446
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: To determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan. Method: A longitudinal 3.0-Tesla (T) magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional (3D) pseudo-continuous arterial spin labeling (pCASL), and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. We examined 23 MDD patients and 26 healthy controls. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period. Results: Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters, a significant decrease in perfusion in the frontal lobes and the ACC in non-remitters compared with healthy controls at baseline and significantly reduced N-acetylaspartate, myo-inositol, and glutamate levels in MDD patients compared with healthy controls at baseline. Conclusion: Using novel MRI techniques, we have found abnormalities in cerebral regions related to cortical-limbic pathways in MDD patients.
Nyckelord
- major depressive disorder
- longitudinal study
- magnetic resonance imaging
- perfusion
- magnetic resonance spectroscopy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas