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Time Trends in Risk...
Time Trends in Risk and Risk Determinants of Non-Hodgkin Lymphoma in Solid Organ Transplant Recipients
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Fernberg, P. (författare)
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- Edgren, G. (författare)
- Karolinska Institutet
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Adami, J. (författare)
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- Ingvar, Å. (författare)
- Karolinska Institutet
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- Bellocco, R. (författare)
- Karolinska Institutet
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- Tufveson, Gunnar (författare)
- Uppsala universitet,Transplantationskirurgi
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- Höglund, P. (författare)
- Karolinska Institutet
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- Kinch, Amelie (författare)
- Uppsala universitet,Infektionssjukdomar
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- Simard, J. F. (författare)
- Karolinska Institutet
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- Baecklund, Eva (författare)
- Uppsala universitet,Reumatologi
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- Lindelöf, B. (författare)
- Karolinska Institutet
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- Pawitan, Y. (författare)
- Karolinska Institutet
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- Smedby, K. E. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 11:11, s. 2472-2482
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Organ transplantation increases risk of non-Hodgkin lymphoma (NHL), but long-term risk and time trends have seldom been evaluated. Immunosuppressive drug load is an important risk determinant, but the details are unclear. We studied NHL risk in a nationwide Swedish cohort of 11 081 graft recipients transplanted 1970-2008. Relative risks (RRs) were estimated within the cohort and versus the general population by age, sex, follow-up time and calendar period. NHL risk was also assessed by cumulative and average doses of immunosuppressive treatments in a nested case-control design throughout 1997 using conditional logistic regression. We observed 153 NHL cases during 97 853 years of follow-up. Compared with the general population, NHL risk was eightfold increased (RR 7.9; 95% confidence interval [CI] 6.6-9.4), and increased risks persisted after >= 15 years of follow-up among kidney (6.1; 95% CI 3.5-10) and nonkidney recipients (44; 14-103). Among nonkidney recipients, NHL risk was lower in the 2000s compared with the 1990s (0.5; 95% CI 0.3-1.0; p = 0.04). A high average dose of antithymocyte immunoglobulin (ATG) conferred an eightfold increased risk of NHL (OR 8.5; 95% CI 1.9-38). To conclude, posttransplant NHL risk decreased during the last decade among nonkidney recipients, possibly because of a more careful use of ATG, the introduction of new drugs, or both.
Nyckelord
- Antithymocyte immunoglobulin
- Epstein-Barr virus
- immunosuppression
- non-Hodgkin lymphoma
- organ transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Fernberg, P.
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Edgren, G.
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Adami, J.
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Ingvar, Å.
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Bellocco, R.
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Tufveson, Gunnar
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visa fler...
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Höglund, P.
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Kinch, Amelie
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Simard, J. F.
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Baecklund, Eva
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Lindelöf, B.
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Pawitan, Y.
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Smedby, K. E.
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visa färre...
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet