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Preferential Associ...
Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies
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- Wang, Chuan (författare)
- Uppsala universitet,Molekylär medicin
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- Kokkonen, Heidi (författare)
- Umeå universitet,Reumatologi
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- Sandling, Johanna K. (författare)
- Uppsala universitet,Molekylär medicin
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- Johansson, Martin (författare)
- Umeå universitet,Reumatologi
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- Seddighzadeh, Maria (författare)
- Karolinska Institutet
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- Padyukov, Leonid (författare)
- Karolinska Institutet
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå universitet,Reumatologi
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- Syvänen, Ann-Christine (författare)
- Uppsala universitet,Molekylär medicin
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(creator_code:org_t)
- 2011-08-01
- 2011
- Engelska.
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Ingår i: Journal of Rheumatology. - Toronto : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 38:10, s. 2130-2132
- Relaterad länk:
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http://www.jrheum.or...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective.Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA).Methods.A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA).Results.The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 × 10−5) and ACPA-negative (OR 1.27, p = 7.3 × 10−5) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 × 10−3).Conclusion.Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- rheumatoid arthritis
- interferon regulatory factor 5
- genetic association study
- seronegative
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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