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Allele-specific cop...
Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity
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- Rasmussen, Markus (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Cancer pharmacology and Computational medicine, Science for Life Laboratory
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- Sundström, Magnus (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Kultima, Hanna Göransson (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Cancer pharmacology and Computatinal medicine, Science for Life Laboratory
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- Botling, Johan (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Micke, Patrick (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Birgisson, Helgi (author)
- Uppsala universitet,Kolorektalkirurgi
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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- Isaksson, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Cancer pharmacology and Computational medicine, Science for Life Laboratory
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2011
- 2011
- English.
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In: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 12:10, s. R108-
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://genomebiolog...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- We describe a bioinformatic tool, Tumor Aberration Prediction Suite (TAPS), for the identification of allele-specific copy numbers in tumor samples using data from Affymetrix SNP arrays. It includes detailed visualization of genomic segment characteristics and iterative pattern recognition for copy number identification, and does not require patient-matched normal samples. TAPS can be used to identify chromosomal aberrations with high sensitivity even when the proportion of tumor cells is as low as 30%. Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and tumor heterogeneity, which is commonly found in many types of solid tumors.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Bioinformatik
- Bioinformatics
Publication and Content Type
- ref (subject category)
- art (subject category)
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